ZnCl2 catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole

Md A. Rahman; Mohammad R. Karim; Md Arifuzzaman; Tasneem A. Siddiquee; Aminul H. Mirza

doi:10.1016/j.tetlet.2014.04.046

ZnCl₂ catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole

Md A. Rahman
, Mohammad R. Karim
, Md Arifuzzaman
, Tasneem A. Siddiquee
, Aminul H. Mirza

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

New methods for the synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl ₂. 1,3,4-Thiadiazoles are formed in the presence of ZnCl₂ alone, whereas oxadiazoles are produced when a base such as Et₃N or KOH was used along with ZnCl₂. % Yields are optimized.

Original language	English
Pages (from-to)	3267-3273
Number of pages	7
Journal	Tetrahedron Letters
Volume	55
Issue number	21
DOIs	https://doi.org/10.1016/j.tetlet.2014.04.046
State	Published - May 21 2014
Externally published	Yes

Keywords

1,3,4-Oxadiazole
1,3,4-Thiadiazole
Phenanthroline

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10.1016/j.tetlet.2014.04.046

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@article{5479ca837224433eab935976bd47cb6d,

title = "ZnCl2 catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole",

abstract = "New methods for the synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl 2. 1,3,4-Thiadiazoles are formed in the presence of ZnCl2 alone, whereas oxadiazoles are produced when a base such as Et3N or KOH was used along with ZnCl2. \% Yields are optimized.",

keywords = "1,3,4-Oxadiazole, 1,3,4-Thiadiazole, Phenanthroline",

author = "Rahman, \{Md A.\} and Karim, \{Mohammad R.\} and Md Arifuzzaman and Siddiquee, \{Tasneem A.\} and Mirza, \{Aminul H.\}",

year = "2014",

month = may,

day = "21",

doi = "10.1016/j.tetlet.2014.04.046",

language = "English",

volume = "55",

pages = "3267--3273",

journal = "Tetrahedron Letters",

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publisher = "Elsevier",

number = "21",

}

TY - JOUR

T1 - ZnCl2 catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole

AU - Rahman, Md A.

AU - Karim, Mohammad R.

AU - Arifuzzaman, Md

AU - Siddiquee, Tasneem A.

AU - Mirza, Aminul H.

PY - 2014/5/21

Y1 - 2014/5/21

N2 - New methods for the synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl 2. 1,3,4-Thiadiazoles are formed in the presence of ZnCl2 alone, whereas oxadiazoles are produced when a base such as Et3N or KOH was used along with ZnCl2. % Yields are optimized.

AB - New methods for the synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl 2. 1,3,4-Thiadiazoles are formed in the presence of ZnCl2 alone, whereas oxadiazoles are produced when a base such as Et3N or KOH was used along with ZnCl2. % Yields are optimized.

KW - 1,3,4-Oxadiazole

KW - 1,3,4-Thiadiazole

KW - Phenanthroline

UR - https://www.scopus.com/pages/publications/84900514783

U2 - 10.1016/j.tetlet.2014.04.046

DO - 10.1016/j.tetlet.2014.04.046

M3 - Article

AN - SCOPUS:84900514783

SN - 0040-4039

VL - 55

SP - 3267

EP - 3273

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

ZnCl₂ catalyzed efficient synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole

Abstract

Keywords

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