X-ray diffraction imaging of glioblastoma and ductal carcinoma in-situ

Joel A. Greenberg, Turner Richmond, Zachary W. Gude, Xiang Li, Arnav Nanda, David Coccarelli, Rachel Factor, Shannon McCall, Anuj Kapadia

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Specimen radiography is critical to cancer diagnostics, but conventional transmission X-ray imaging often lacks the contrast to conclusively differentiate healthy from cancerous tissue. X-ray diffraction (XRD), however, has been shown to be sensitive to structural changes in tissue that are correlated with cancer progression. We use a home-built XRD imaging system to study glioblastoma in brain tissue and ductal carcinoma in situ (DCIS) in breast tissue, and identify both commonalities and unique aspects of cancer structural changes in the brain and breast. These findings demonstrate the potential for XRD imaging as a new tool for use in both research and diagnostic medicine.

Original languageEnglish
Title of host publicationMedical Imaging 2024
Subtitle of host publicationPhysics of Medical Imaging
EditorsRebecca Fahrig, John M. Sabol, Ke Li
PublisherSPIE
ISBN (Electronic)9781510671546
DOIs
StatePublished - 2024
Externally publishedYes
EventMedical Imaging 2024: Physics of Medical Imaging - San Diego, United States
Duration: Feb 19 2024Feb 22 2024

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12925
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2024: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego
Period02/19/2402/22/24

Keywords

  • DCIS
  • X-ray diffraction
  • X-ray diffraction imaging
  • X-ray imaging
  • brain
  • cancer
  • coded aperture

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