@article{920ee697cf5643518f1fb27d372163fc,
title = "Water soluble complexes of chitosan-g-MPEG and hyaluronic acid",
abstract = "Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).",
keywords = "Chitosan-g-MPEG, Hyaluronic acid, Polyelectrolyte complex, Rheology, SAXS",
author = "Jun Wu and Xuefen Wang and Keum, {Jong Kahk} and Hongwen Zhou and Mikhail Gelfer and Avila-Orta, {Carlos Alberto} and Hui Pan and Weiliam Chen and Chiao, {Shu Min} and Hsiao, {Benjamin S.} and Benjamin Chu",
year = "2007",
month = mar,
day = "15",
doi = "10.1002/jbm.a.30972",
language = "English",
volume = "80",
pages = "800--812",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "1549-3296",
publisher = "wiley",
number = "4",
}