Water soluble complexes of chitosan-g-MPEG and hyaluronic acid

Jun Wu; Xuefen Wang; Jong Kahk Keum; Hongwen Zhou; Mikhail Gelfer; Carlos Alberto Avila-Orta; Hui Pan; Weiliam Chen; Shu Min Chiao; Benjamin S. Hsiao; Benjamin Chu

doi:10.1002/jbm.a.30972

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid

Jun Wu, Xuefen Wang, Jong Kahk Keum, Hongwen Zhou, Mikhail Gelfer, Carlos Alberto Avila-Orta, Hui Pan, Weiliam Chen, Shu Min Chiao, Benjamin S. Hsiao, Benjamin Chu

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).

Original language	English
Pages (from-to)	800-812
Number of pages	13
Journal	Journal of Biomedical Materials Research - Part A
Volume	80
Issue number	4
DOIs	https://doi.org/10.1002/jbm.a.30972
State	Published - Mar 15 2007
Externally published	Yes

Keywords

Chitosan-g-MPEG
Hyaluronic acid
Polyelectrolyte complex
Rheology
SAXS

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10.1002/jbm.a.30972

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title = "Water soluble complexes of chitosan-g-MPEG and hyaluronic acid",

abstract = "Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).",

keywords = "Chitosan-g-MPEG, Hyaluronic acid, Polyelectrolyte complex, Rheology, SAXS",

author = "Jun Wu and Xuefen Wang and Keum, {Jong Kahk} and Hongwen Zhou and Mikhail Gelfer and Avila-Orta, {Carlos Alberto} and Hui Pan and Weiliam Chen and Chiao, {Shu Min} and Hsiao, {Benjamin S.} and Benjamin Chu",

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AU - Wu, Jun

AU - Wang, Xuefen

AU - Keum, Jong Kahk

AU - Zhou, Hongwen

AU - Gelfer, Mikhail

AU - Avila-Orta, Carlos Alberto

AU - Pan, Hui

AU - Chen, Weiliam

AU - Chiao, Shu Min

AU - Hsiao, Benjamin S.

AU - Chu, Benjamin

PY - 2007/3/15

Y1 - 2007/3/15

N2 - Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).

AB - Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).

KW - Chitosan-g-MPEG

KW - Hyaluronic acid

KW - Polyelectrolyte complex

KW - Rheology

KW - SAXS

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JO - Journal of Biomedical Materials Research - Part A

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ER -

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid

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Keywords

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