Water and lipid bilayers

Jonathan D. Nickels; John Katsaras

doi:10.1007/978-3-319-19060-0_3

Water and lipid bilayers

Jonathan D. Nickels, John Katsaras

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Water is crucial to the structure and function of biological membranes. In fact, the membrane’s basic structural unit, i.e. the lipid bilayer, is self-assembled and stabilized by the so-called hydrophobic effect, whereby lipid molecules unable to hydrogen bond with water aggregate in order to prevent their hydrophobic portions from being exposed to water. However, this is just the beginning of the lipid-bilayer-water relationship. This mutual interaction defines vesicle stability in solution, controls small molecule permeation, and defines the spacing between lamella in multi-lamellar systems, to name a few examples. This chapter will describe the structural and dynamical properties central to these, and other water- lipid bilayer interactions.

Original language	English
Pages (from-to)	45-67
Number of pages	23
Journal	Sub-Cellular Biochemistry
Volume	71
DOIs	https://doi.org/10.1007/978-3-319-19060-0_3
State	Published - 2015

Funding

Support for the authors was received from the Department of Energy (DOE), Scientific User Facilities Division, Office of Basic Energy Sciences (BES) through Oak Ridge National Laboratory (ORNL), which is managed by UT-Battelle, LLC, for the U.S. DOE under contract no. DE-AC05-00OR2275. JDN was partially supported through EPSCoR grant no. DEFG02-08ER46528.

Funders	Funder number
Scientific User Facilities Division
U.S. Department of Energy
U.S. Department of Energy
Office of Experimental Program to Stimulate Competitive Research	DEFG02-08ER46528
Office of Experimental Program to Stimulate Competitive Research
Basic Energy Sciences
Oak Ridge National Laboratory	DE-AC05-00OR2275
Oak Ridge National Laboratory

Keywords

Dynamics
Permeation
Water distribution

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10.1007/978-3-319-19060-0_3

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AB - Water is crucial to the structure and function of biological membranes. In fact, the membrane’s basic structural unit, i.e. the lipid bilayer, is self-assembled and stabilized by the so-called hydrophobic effect, whereby lipid molecules unable to hydrogen bond with water aggregate in order to prevent their hydrophobic portions from being exposed to water. However, this is just the beginning of the lipid-bilayer-water relationship. This mutual interaction defines vesicle stability in solution, controls small molecule permeation, and defines the spacing between lamella in multi-lamellar systems, to name a few examples. This chapter will describe the structural and dynamical properties central to these, and other water- lipid bilayer interactions.

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JO - Sub-Cellular Biochemistry

JF - Sub-Cellular Biochemistry

ER -

Water and lipid bilayers

Abstract

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Keywords

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