Using neutron protein crystallography to understand enzyme mechanisms

Jenny P. Glusker; H. L. Carrell; Andrey Y. Kovalevsky; Leif Hanson; S. Zoe Fisher; Marat Mustyakimov; Sax Mason; Trevor Forsyth; Paul Langan

doi:10.1107/S0907444910027915

Using neutron protein crystallography to understand enzyme mechanisms

Jenny P. Glusker, H. L. Carrell, Andrey Y. Kovalevsky, Leif Hanson, S. Zoe Fisher, Marat Mustyakimov, Sax Mason, Trevor Forsyth, Paul Langan

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8 Scopus citations

Abstract

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

Original language	English
Pages (from-to)	1257-1261
Number of pages	5
Journal	Acta Crystallographica Section D: Biological Crystallography
Volume	66
Issue number	11
DOIs	https://doi.org/10.1107/S0907444910027915
State	Published - Nov 2010

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title = "Using neutron protein crystallography to understand enzyme mechanisms",

abstract = "A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.",

author = "Glusker, \{Jenny P.\} and Carrell, \{H. L.\} and Kovalevsky, \{Andrey Y.\} and Leif Hanson and Fisher, \{S. Zoe\} and Marat Mustyakimov and Sax Mason and Trevor Forsyth and Paul Langan",

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doi = "10.1107/S0907444910027915",

language = "English",

volume = "66",

pages = "1257--1261",

journal = "Acta Crystallographica Section D: Biological Crystallography",

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T1 - Using neutron protein crystallography to understand enzyme mechanisms

AU - Glusker, Jenny P.

AU - Carrell, H. L.

AU - Kovalevsky, Andrey Y.

AU - Hanson, Leif

AU - Fisher, S. Zoe

AU - Mustyakimov, Marat

AU - Mason, Sax

AU - Forsyth, Trevor

AU - Langan, Paul

PY - 2010/11

Y1 - 2010/11

N2 - A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

AB - A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

UR - https://www.scopus.com/pages/publications/78049452648

U2 - 10.1107/S0907444910027915

DO - 10.1107/S0907444910027915

M3 - Article

C2 - 21041947

AN - SCOPUS:78049452648

SN - 0907-4449

VL - 66

SP - 1257

EP - 1261

JO - Acta Crystallographica Section D: Biological Crystallography

JF - Acta Crystallographica Section D: Biological Crystallography

IS - 11

ER -

Using neutron protein crystallography to understand enzyme mechanisms

Abstract

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