Using neutron protein crystallography to understand enzyme mechanisms

Jenny P. Glusker; H. L. Carrell; Andrey Y. Kovalevsky; Leif Hanson; S. Zoe Fisher; Marat Mustyakimov; Sax Mason; Trevor Forsyth; Paul Langan

doi:10.1107/S0907444910027915

Using neutron protein crystallography to understand enzyme mechanisms

Jenny P. Glusker
, H. L. Carrell
, Andrey Y. Kovalevsky
, Leif Hanson
, S. Zoe Fisher
, Marat Mustyakimov
, Sax Mason
, Trevor Forsyth
, Paul Langan

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

Original language	English
Pages (from-to)	1257-1261
Number of pages	5
Journal	Acta Crystallographica Section D: Biological Crystallography
Volume	66
Issue number	11
DOIs	https://doi.org/10.1107/S0907444910027915
State	Published - Nov 2010
Externally published	Yes

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title = "Using neutron protein crystallography to understand enzyme mechanisms",

abstract = "A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.",

author = "Glusker, \{Jenny P.\} and Carrell, \{H. L.\} and Kovalevsky, \{Andrey Y.\} and Leif Hanson and Fisher, \{S. Zoe\} and Marat Mustyakimov and Sax Mason and Trevor Forsyth and Paul Langan",

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doi = "10.1107/S0907444910027915",

language = "English",

volume = "66",

pages = "1257--1261",

journal = "Acta Crystallographica Section D: Biological Crystallography",

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T1 - Using neutron protein crystallography to understand enzyme mechanisms

AU - Glusker, Jenny P.

AU - Carrell, H. L.

AU - Kovalevsky, Andrey Y.

AU - Hanson, Leif

AU - Fisher, S. Zoe

AU - Mustyakimov, Marat

AU - Mason, Sax

AU - Forsyth, Trevor

AU - Langan, Paul

PY - 2010/11

Y1 - 2010/11

N2 - A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

AB - A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

UR - https://www.scopus.com/pages/publications/78049452648

U2 - 10.1107/S0907444910027915

DO - 10.1107/S0907444910027915

M3 - Article

C2 - 21041947

AN - SCOPUS:78049452648

SN - 0907-4449

VL - 66

SP - 1257

EP - 1261

JO - Acta Crystallographica Section D: Biological Crystallography

JF - Acta Crystallographica Section D: Biological Crystallography

IS - 11

ER -

Using neutron protein crystallography to understand enzyme mechanisms

Abstract

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