Using neutron protein crystallography to understand enzyme mechanisms

Jenny P. Glusker, H. L. Carrell, Andrey Y. Kovalevsky, Leif Hanson, S. Zoe Fisher, Marat Mustyakimov, Sax Mason, Trevor Forsyth, Paul Langan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

Original languageEnglish
Pages (from-to)1257-1261
Number of pages5
JournalActa Crystallographica Section D: Biological Crystallography
Volume66
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

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