Ultra-small and size tunable PVP-NaGdF4:Dy nanoparticles with high biocompatibility for multimodal tumor imaging

Min Yang, Tao Wang, Ying Wang, Chunhuan Jiang, Jinxing Chen, Yanzhi Zhao, Honglei Wang, Yu Jiang, Guoying Sun, Jianhua Liu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Multimodal imaging nanoprobes by integrating different imaging functions into one nanoplatform can provide more comprehensive and accurate information for the detection of tumors at their early stage, which is crucial to decrease the mortality rate. In this report, highly monodisperse Dy doped NaGdF4 NPs with ultra-small size (2.51 nm and 8.62 nm) were synthesized through a one-step and versatile thermal decomposition method. Then a facile ligand exchange strategy was applied to replace the passivating oleate ligand with an amphiphilic polymer of polyvinylpyrrolidone (PVP). These PVP-NPs not only showed an improved longitudinal relaxivity (r1 = 6.17 mM−1 s−1) and a higher transverse relaxivity (r2 = 13.82 mM−1 s−1), but also possessed strong X-ray attenuation properties (48.54 HU L g−1). MTT assay, histological analysis and body weight assessment illustrated that the multifunctional NPs were of relatively low toxicity. The influence of particle size on toxicity, biodistribution, elimination pathway and relaxivity was systematically explored. Furthermore, in vivo MR and CT imaging demonstrated that there was considerable signal enhancement in liver, spleen and tumor through intravenous injection. Therefore, it is envisioned that the PVP-NaGdF4:Dy NPs can serve as potential T1- and T2-weighted MR and CT imaging contrast agents.

Original languageEnglish
Pages (from-to)106355-106363
Number of pages9
JournalRSC Advances
Volume6
Issue number108
DOIs
StatePublished - 2016
Externally publishedYes

Funding

Financial support by the National Natural Science Foundation of China (No. 21003013), the Natural Science Foundation of Jilin Provincial Science and Technology Department (No. 201215126) and Jilin Provincial Education Department (No. 2016323).

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