Tripodal Half-Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

Andrew R. Burgoyne; Catherine H. Kaschula; M. Iqbal Parker; Gregory S. Smith

doi:10.1002/ejic.201700704

Tripodal Half-Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

Andrew R. Burgoyne, Catherine H. Kaschula, M. Iqbal Parker, Gregory S. Smith

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

In light of the widely used platinum anticancer drugs showing high toxicity and poor selectivity, the quest to develop new anticancer agents is increasing. This study investigated the synthesis of mononuclear and trinuclear Rh^III and Ir^III sulfonate-containing pyridinyl complexes that have been fully characterized using NMR and IR spectroscopy, HR-ESI-mass spectrometry and elemental analysis. The cytotoxicities of all sulfonated pyridinyl compounds were investigated against a WHCO1 oesophageal cancer cell line and the metal complexes showed moderate activity, while the uncomplexed ligands were inactive. Several of the trinuclear complexes are of comparable activity to that of the clinical cancer drug cisplatin. ¹H NMR model studies demonstrated the in vitro DNA binding ability of the most active complex.

Original language	English
Pages (from-to)	5379-5386
Number of pages	8
Journal	European Journal of Inorganic Chemistry
Volume	2017
Issue number	45
DOIs	https://doi.org/10.1002/ejic.201700704
State	Published - Dec 8 2017
Externally published	Yes

Funding

Financial support from the University of Cape Town, the National Research Foundation (NRF) of South Africa (Grant no.: 90500) and the Cancer Association of South Africa is gratefully acknowledged.

Funders	Funder number
National Research Foundation
National Research Foundation	90500
Cancer Association of South Africa
University of Cape Town

Keywords

Antitumor agents
Bioinorganic chemistry
DNA binding
Half-sandwich complexes
Sulfonates

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ejic.201700704

Cite this

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title = "Tripodal Half-Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents",

abstract = "In light of the widely used platinum anticancer drugs showing high toxicity and poor selectivity, the quest to develop new anticancer agents is increasing. This study investigated the synthesis of mononuclear and trinuclear RhIII and IrIII sulfonate-containing pyridinyl complexes that have been fully characterized using NMR and IR spectroscopy, HR-ESI-mass spectrometry and elemental analysis. The cytotoxicities of all sulfonated pyridinyl compounds were investigated against a WHCO1 oesophageal cancer cell line and the metal complexes showed moderate activity, while the uncomplexed ligands were inactive. Several of the trinuclear complexes are of comparable activity to that of the clinical cancer drug cisplatin. 1H NMR model studies demonstrated the in vitro DNA binding ability of the most active complex.",

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AU - Burgoyne, Andrew R.

AU - Kaschula, Catherine H.

AU - Parker, M. Iqbal

AU - Smith, Gregory S.

PY - 2017/12/8

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N2 - In light of the widely used platinum anticancer drugs showing high toxicity and poor selectivity, the quest to develop new anticancer agents is increasing. This study investigated the synthesis of mononuclear and trinuclear RhIII and IrIII sulfonate-containing pyridinyl complexes that have been fully characterized using NMR and IR spectroscopy, HR-ESI-mass spectrometry and elemental analysis. The cytotoxicities of all sulfonated pyridinyl compounds were investigated against a WHCO1 oesophageal cancer cell line and the metal complexes showed moderate activity, while the uncomplexed ligands were inactive. Several of the trinuclear complexes are of comparable activity to that of the clinical cancer drug cisplatin. 1H NMR model studies demonstrated the in vitro DNA binding ability of the most active complex.

AB - In light of the widely used platinum anticancer drugs showing high toxicity and poor selectivity, the quest to develop new anticancer agents is increasing. This study investigated the synthesis of mononuclear and trinuclear RhIII and IrIII sulfonate-containing pyridinyl complexes that have been fully characterized using NMR and IR spectroscopy, HR-ESI-mass spectrometry and elemental analysis. The cytotoxicities of all sulfonated pyridinyl compounds were investigated against a WHCO1 oesophageal cancer cell line and the metal complexes showed moderate activity, while the uncomplexed ligands were inactive. Several of the trinuclear complexes are of comparable activity to that of the clinical cancer drug cisplatin. 1H NMR model studies demonstrated the in vitro DNA binding ability of the most active complex.

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KW - Sulfonates

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Tripodal Half-Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

Abstract

Funding

Keywords

UN SDGs

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