Trinuclear half-sandwich RuII, RhIII and IrIII polyester organometallic complexes: Synthesis and in vitro evaluation as antitumor agents

Andrew R. Burgoyne, Banothile C.E. Makhubela, Mervin Meyer, Gregory S. Smith

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either 2-pyridinecarboxaldehyde or salicylaldehyde were used to synthesise bidentate trimeric ester ligands. The trimeric ester ligands were used to prepare a new series of trinuclear polyester organometallic complexes by using the dimeric precursors, [Ru(η6-p-iPrC6H4Me)Cl2]2, [Rh(C5Me5)Cl2]2 or [Ir(C5Me5)Cl2]2. The Schiff base ligands act as bidentate donors to each metal. All compounds were characterised by NMR and IR spectroscopy, elemental analysis and EI/ESI mass spectrometry. Model mononuclear analogues were prepared, and the molecular structures of selected compounds were determined by single-crystal X-ray diffraction analysis. The mono- and trimeric ligands and the metal complexes were evaluated for inhibitory effects against the human ovarian cancer cell lines, A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant), and the model human skin fibroblast cell line, KMST-6. Polyester-containing trinuclear half-sandwich RuII, RhIII and IrIII complexes were prepared and characterised. The cytotoxicity was investigated for all compounds. Aqueous stability studies and interactions with model DNA 5′-GMP were performed for the most-active compounds.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalEuropean Journal of Inorganic Chemistry
Volume2015
Issue number8
DOIs
StatePublished - Mar 2015
Externally publishedYes

Keywords

  • Antitumor agents
  • Bioorganometallic chemistry
  • Half-sandwich complexes
  • Polyesters

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