TY - GEN
T1 - Transparent microarrays of vertically aligned carbon nanofibers as a multimodal tissue interface
AU - Hensley, Dale K.
AU - Melechko, Anatoli V.
AU - Ericson, M. Nance
AU - Simpson, Michael L.
AU - McKnight, Timothy E.
PY - 2010
Y1 - 2010
N2 - The incorporation of nanostructured materials as functional elements of microscale devices can enhance the application of these systems for biological interfacing. Vertically aligned carbon nanofibers (VACNFs) have been applied as highly spatially resolved electrodes in electrophysiological interfacing to tissue. Further, their high aspect ratio enables them to penetrate into cells of tissue matrices for intracellular molecular manipulation. To date, studies investigating the interactions of VACNFs with cellular processes have been limited by the use of opaque substrate materials (predominantly silicon) which interferes with optical imaging. In this paper, we discuss improved methods for fabrication of VACNF-based devices on transparent, fused silica substrates and provide data regarding the application of these devices for multimodal neuronal interfacing, including both electrophysiological and genetic manipulation of tissue.
AB - The incorporation of nanostructured materials as functional elements of microscale devices can enhance the application of these systems for biological interfacing. Vertically aligned carbon nanofibers (VACNFs) have been applied as highly spatially resolved electrodes in electrophysiological interfacing to tissue. Further, their high aspect ratio enables them to penetrate into cells of tissue matrices for intracellular molecular manipulation. To date, studies investigating the interactions of VACNFs with cellular processes have been limited by the use of opaque substrate materials (predominantly silicon) which interferes with optical imaging. In this paper, we discuss improved methods for fabrication of VACNF-based devices on transparent, fused silica substrates and provide data regarding the application of these devices for multimodal neuronal interfacing, including both electrophysiological and genetic manipulation of tissue.
UR - http://www.scopus.com/inward/record.url?scp=77955612087&partnerID=8YFLogxK
U2 - 10.1109/BSEC.2010.5510801
DO - 10.1109/BSEC.2010.5510801
M3 - Conference contribution
AN - SCOPUS:77955612087
SN - 9781424467143
T3 - Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
BT - Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010
T2 - 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
Y2 - 25 May 2010 through 26 May 2010
ER -