Toxic and teratogenic effects of chemical class fractions of a coal-gasification electrostatic precipitator tar

T. Wayne Schultz; James N. Dumont; Michelle V. Buchanan

doi:10.1016/0300-483X(83)90041-0

Toxic and teratogenic effects of chemical class fractions of a coal-gasification electrostatic precipitator tar

T. Wayne Schultz, James N. Dumont, Michelle V. Buchanan

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8 Scopus citations

Abstract

Dimethyl sulfoxide slurries of a coal gasifier electrostatic precipitator tar and its chemical class fractions were assayed for their toxicity and teratogenicity using early embryos of the frog Xenopus laevis. Of the 5 tar fractions the ether-soluble base and polyaromatic were found to be the most teratogenic and the ether-soluble acid and ether-soluble base were the most toxic. The teratogenic effects of the raw tar suggest synergism. The toxic effects to newly metamorphosed froglets is 1-2 orders of magnitude less than those observed for embryos. Chemical analysis shows dihydroxybenzenes and organonitrogen compounds to be the major components of the acid and base fractions, respectively. The neutral fractions contain mainly alkyl-substituted two-ring hydrocarbons.

Original language	English
Pages (from-to)	87-99
Number of pages	13
Journal	Toxicology
Volume	29
Issue number	1-2
DOIs	https://doi.org/10.1016/0300-483X(83)90041-0
State	Published - Dec 1983

Funding

The authors gratefully acknowledge the assistance of Ms. Rhonda Elper in conducting the bioassays and C.,h. Ho for the class fractionation of the tar. This research sponsored jointly by the U.S. Environmental Protection Agency under interagency agreement No. 79-D-X0533 and 79°D-X0521 and by the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation. Although the research described in this article has been funded whoily or in part by the United States Environmental Protection Agency through Interagency Agreement No. 79°D-X0533 and 79°D-X0521 to U.S. Department of Energy, it has not been subjected to EPA review and therefore does not necessarily reflect the views of the EPA and no official endorsement should be inferred.

Funders	Funder number
Office of Health and Environmental Research
U.S. Department of Energy	W-7405-eng-26
U.S. Department of Energy
U.S. Environmental Protection Agency	D-X0521, 79°D-X0533, 79°D-X0521
U.S. Environmental Protection Agency

Keywords

Amphibian model
Coal-gasifier
Teratogenicity
Toxicity

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10.1016/0300-483X(83)90041-0

Cite this

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title = "Toxic and teratogenic effects of chemical class fractions of a coal-gasification electrostatic precipitator tar",

abstract = "Dimethyl sulfoxide slurries of a coal gasifier electrostatic precipitator tar and its chemical class fractions were assayed for their toxicity and teratogenicity using early embryos of the frog Xenopus laevis. Of the 5 tar fractions the ether-soluble base and polyaromatic were found to be the most teratogenic and the ether-soluble acid and ether-soluble base were the most toxic. The teratogenic effects of the raw tar suggest synergism. The toxic effects to newly metamorphosed froglets is 1-2 orders of magnitude less than those observed for embryos. Chemical analysis shows dihydroxybenzenes and organonitrogen compounds to be the major components of the acid and base fractions, respectively. The neutral fractions contain mainly alkyl-substituted two-ring hydrocarbons.",

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author = "{Wayne Schultz}, T. and Dumont, {James N.} and Buchanan, {Michelle V.}",

year = "1983",

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doi = "10.1016/0300-483X(83)90041-0",

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T1 - Toxic and teratogenic effects of chemical class fractions of a coal-gasification electrostatic precipitator tar

AU - Wayne Schultz, T.

AU - Dumont, James N.

AU - Buchanan, Michelle V.

PY - 1983/12

Y1 - 1983/12

N2 - Dimethyl sulfoxide slurries of a coal gasifier electrostatic precipitator tar and its chemical class fractions were assayed for their toxicity and teratogenicity using early embryos of the frog Xenopus laevis. Of the 5 tar fractions the ether-soluble base and polyaromatic were found to be the most teratogenic and the ether-soluble acid and ether-soluble base were the most toxic. The teratogenic effects of the raw tar suggest synergism. The toxic effects to newly metamorphosed froglets is 1-2 orders of magnitude less than those observed for embryos. Chemical analysis shows dihydroxybenzenes and organonitrogen compounds to be the major components of the acid and base fractions, respectively. The neutral fractions contain mainly alkyl-substituted two-ring hydrocarbons.

AB - Dimethyl sulfoxide slurries of a coal gasifier electrostatic precipitator tar and its chemical class fractions were assayed for their toxicity and teratogenicity using early embryos of the frog Xenopus laevis. Of the 5 tar fractions the ether-soluble base and polyaromatic were found to be the most teratogenic and the ether-soluble acid and ether-soluble base were the most toxic. The teratogenic effects of the raw tar suggest synergism. The toxic effects to newly metamorphosed froglets is 1-2 orders of magnitude less than those observed for embryos. Chemical analysis shows dihydroxybenzenes and organonitrogen compounds to be the major components of the acid and base fractions, respectively. The neutral fractions contain mainly alkyl-substituted two-ring hydrocarbons.

KW - Amphibian model

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KW - Teratogenicity

KW - Toxicity

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ER -

Toxic and teratogenic effects of chemical class fractions of a coal-gasification electrostatic precipitator tar

Abstract

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Keywords

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