Towards simulations of outer membrane proteins in lipopolysaccharide membranes

T. A. Soares, T. P. Straatsma

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

7 Scopus citations

Abstract

Atomistic simulations of the outer membrane of Pseudomonas aeruginosa constituted of monolayers with 64 LPS molecules and 160 PE molecules were performed. The Amber96 force field and our extensions of the Glycam93 force field were used together with periodic boundary conditions the smooth Particle Mesh Ewald method. Simulation derived properties of LPS membranes are shown to exhibit good agreement with available experimental data within the time scale simulated, chosen force field and simulation conditions. The molecular model used offers an accurate representation the high asymmetry and low fluidity characteristics of outer membranes.

Original languageEnglish
Title of host publicationComputation in Modern Science and Engineering - Proceedings of the International Conference on Computational Methods in Science and Engineering 2007 (ICCMSE 2007)
Pages1375-1378
Number of pages4
Edition2
DOIs
StatePublished - 2007
Externally publishedYes
EventInternational Conference on Computational Methods in Science and Engineering 2007, ICCMSE 2007 - Corfu, Greece
Duration: Sep 25 2007Sep 30 2007

Publication series

NameAIP Conference Proceedings
Number2
Volume963
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Computational Methods in Science and Engineering 2007, ICCMSE 2007
Country/TerritoryGreece
CityCorfu
Period09/25/0709/30/07

Keywords

  • Lipopolysaccharide membranes
  • Molecular simulation
  • Outer membrane proteins

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