Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

Gabe Nagy; Dusan Veličković; Rosalie K. Chu; Alyssa A. Carrell; David J. Weston; Yehia M. Ibrahim; Christopher R. Anderton; Richard D. Smith

doi:10.1039/c8cc07482h

Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

Gabe Nagy
, Dusan Veličković
, Rosalie K. Chu
, Alyssa A. Carrell
, David J. Weston
, Yehia M. Ibrahim
, Christopher R. Anderton
, Richard D. Smith

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We demonstrate the coupling of liquid extraction surface analysis (LESA) to structures for lossless ion manipulations in conjunction with serpentine ultralong path with extending routing (SLIM SUPER) ion mobility-mass spectrometry (IM-MS) for the unambiguous annotation of important isomeric glycoforms in carbon-fixing communities.

Original language	English
Pages (from-to)	306-309
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	3
DOIs	https://doi.org/10.1039/c8cc07482h
State	Published - 2019

Funding

Experiments were performed at EMSL, sponsored by the Office of Biological and Environmental Research (BER), U.S. Department of Energy (DOE). EMSL is located at PNNL, a multidisciplinary national laboratory operated by Battelle for the U.S. DOE under contract DE-AC05-76RL0 1830 for the DOE. This work was partially supported by the National Institute of General Medical Sciences (P41 GM103493).

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10.1039/c8cc07482h

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Nagy, G., Veličković, D., Chu, R. K., Carrell, A. A., Weston, D. J., Ibrahim, Y. M., Anderton, C. R., & Smith, R. D. (2019). Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations. Chemical Communications, 55(3), 306-309. https://doi.org/10.1039/c8cc07482h

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title = "Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations",

abstract = "We demonstrate the coupling of liquid extraction surface analysis (LESA) to structures for lossless ion manipulations in conjunction with serpentine ultralong path with extending routing (SLIM SUPER) ion mobility-mass spectrometry (IM-MS) for the unambiguous annotation of important isomeric glycoforms in carbon-fixing communities.",

author = "Gabe Nagy and Dusan Veli{\v c}kovi{\'c} and Chu, \{Rosalie K.\} and Carrell, \{Alyssa A.\} and Weston, \{David J.\} and Ibrahim, \{Yehia M.\} and Anderton, \{Christopher R.\} and Smith, \{Richard D.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c8cc07482h",

language = "English",

volume = "55",

pages = "306--309",

journal = "Chemical Communications",

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Nagy, G, Veličković, D, Chu, RK, Carrell, AA , Weston, DJ, Ibrahim, YM, Anderton, CR & Smith, RD 2019, 'Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations', Chemical Communications, vol. 55, no. 3, pp. 306-309. https://doi.org/10.1039/c8cc07482h

Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations. / Nagy, Gabe; Veličković, Dusan; Chu, Rosalie K. et al.
In: Chemical Communications, Vol. 55, No. 3, 2019, p. 306-309.

Research output: Contribution to journal › Article › peer-review

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AU - Nagy, Gabe

AU - Veličković, Dusan

AU - Chu, Rosalie K.

AU - Carrell, Alyssa A.

AU - Weston, David J.

AU - Ibrahim, Yehia M.

AU - Anderton, Christopher R.

AU - Smith, Richard D.

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AB - We demonstrate the coupling of liquid extraction surface analysis (LESA) to structures for lossless ion manipulations in conjunction with serpentine ultralong path with extending routing (SLIM SUPER) ion mobility-mass spectrometry (IM-MS) for the unambiguous annotation of important isomeric glycoforms in carbon-fixing communities.

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AN - SCOPUS:85059421395

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VL - 55

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EP - 309

JO - Chemical Communications

JF - Chemical Communications

IS - 3

ER -

Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

Abstract

Funding

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