Topography-Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Tae Sik Jang, Seong Je Park, Ji Eun Lee, Jeongho Yang, Suk Hee Park, Martin Byung Guk Jun, Young Won Kim, Clodualdo Aranas, Joon Phil Choi, Yu Zou, Rigoberto C. Advincula, Yufeng Zheng, Hae Lin Jang, Nam Joon Cho, Hyun Do Jung, Sang Hoon Kim

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Orthopedic implants should have sufficient strength and promote bone tissue regeneration. However, most conventional implants are optimized for use either under high mechanical load or for active osseointegration. To achieve the dual target of mechanical durability and biocompatibility, polyether ether ketone (PEEK) filaments reinforced with internal titanium dioxide (TiO2) nanoparticles via dopamine-induced polymerization are additively manufactured into an orthopedic implant through material extrusion (ME). The exterior of the PEEK/TiO2 composite is coated with hydroxyapatite (HA) using radiofrequency (RF) magnetron sputtering to increase both the strength and biocompatibility provided by homogeneous ceramic–ceramic interactions and the protuberant nanoscale topography between the internal TiO2 nanoparticle reinforcement and external HA coating. The hardness, tensile, and compression, and scratch test results demonstrate a considerable enhancement in the mechanical strength of the hierarchical PEEK/TiO2/HA hybrid composite structure compared to that of the conventional 3D-printed PEEK. Furthermore, PEEK with internal TiO2 reinforcement improves the proliferation and differentiation of bone cells in vitro, whereas the external HA coating leads to a more prevalent osteoblast absorption. Micro-computed tomography and histological analyses confirm new bone formation and a high bone-to-implant contact ratio on the HA-coated PEEK structure reinforced with TiO2 nanoparticles.

Original languageEnglish
Article number2206863
JournalAdvanced Functional Materials
Volume32
Issue number51
DOIs
StatePublished - Dec 16 2022

Funding

This work was results of a study on the “Leaders in Industry‐university Cooperation 3.0” Project, supported by the Ministry of Education and National Research Foundation of Korea. In addition, this work was supported by the Catholic University of Korea, Research Fund, 2020, and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1A2C1091301), the Korean Fund for Regenerative Medicine funded by the Ministry of Science and ICT, and by the Ministry of Health and Welfare (2021M3E5E5096420, Republic of Korea).

FundersFunder number
Korean Fund for Regenerative Medicine
Catholic University of Korea
Ministry of Education
Ministry of Science, ICT and Future Planning2021R1A2C1091301
Ministry of Health and Welfare2021M3E5E5096420
National Research Foundation of Korea

    Keywords

    • additive manufacturing
    • dopamine-induced polymerization
    • homogeneous ceramic–ceramic interactions
    • orthopedic implants
    • protuberant nanoscale topography

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