Thermally induced core-shell type hydrogel beads having interpenetrating polymer network (IPN) structure

Tae Gwan Park; Hoo Kyun Choi

doi:10.1002/(sici)1521-3927(19980401)19:4<167::aid-marc167>3.0.co;2-g

Thermally induced core-shell type hydrogel beads having interpenetrating polymer network (IPN) structure

Tae Gwan Park, Hoo Kyun Choi

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Monodisperse hydrogel beads composed of calcium alginate and crosslinked polyNIPAAm (N-isopropylacrylamide) were synthesized based on a simultaneous interpenetrating network process. With increasing the temperature above the phase transition temperature of polyNIPAAm, a core-shell type of hydrogel beads was developed; polyNIPAAm-enriched core region and Ca-alginate-enriched outer shell layer were observed. The thermally reversible formation of the core-shell double structure in the IPN hydrogel beads was applied for the temperature modulated drug release using indomethacin as a model drug.

Original language	English
Pages (from-to)	167-172
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	19
Issue number	4
DOIs	https://doi.org/10.1002/(sici)1521-3927(19980401)19:4<167::aid-marc167>3.0.co;2-g
State	Published - Apr 1998
Externally published	Yes

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10.1002/(sici)1521-3927(19980401)19:4<167::aid-marc167>3.0.co;2-g

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abstract = "Monodisperse hydrogel beads composed of calcium alginate and crosslinked polyNIPAAm (N-isopropylacrylamide) were synthesized based on a simultaneous interpenetrating network process. With increasing the temperature above the phase transition temperature of polyNIPAAm, a core-shell type of hydrogel beads was developed; polyNIPAAm-enriched core region and Ca-alginate-enriched outer shell layer were observed. The thermally reversible formation of the core-shell double structure in the IPN hydrogel beads was applied for the temperature modulated drug release using indomethacin as a model drug.",

author = "Park, {Tae Gwan} and Choi, {Hoo Kyun}",

year = "1998",

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AU - Park, Tae Gwan

AU - Choi, Hoo Kyun

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N2 - Monodisperse hydrogel beads composed of calcium alginate and crosslinked polyNIPAAm (N-isopropylacrylamide) were synthesized based on a simultaneous interpenetrating network process. With increasing the temperature above the phase transition temperature of polyNIPAAm, a core-shell type of hydrogel beads was developed; polyNIPAAm-enriched core region and Ca-alginate-enriched outer shell layer were observed. The thermally reversible formation of the core-shell double structure in the IPN hydrogel beads was applied for the temperature modulated drug release using indomethacin as a model drug.

AB - Monodisperse hydrogel beads composed of calcium alginate and crosslinked polyNIPAAm (N-isopropylacrylamide) were synthesized based on a simultaneous interpenetrating network process. With increasing the temperature above the phase transition temperature of polyNIPAAm, a core-shell type of hydrogel beads was developed; polyNIPAAm-enriched core region and Ca-alginate-enriched outer shell layer were observed. The thermally reversible formation of the core-shell double structure in the IPN hydrogel beads was applied for the temperature modulated drug release using indomethacin as a model drug.

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JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 4

ER -

Thermally induced core-shell type hydrogel beads having interpenetrating polymer network (IPN) structure

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