Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages: An Inorganic Mimic of K+Ion Channels

Yunyi Gao; Jennifer E.S. Szymanowski; Xinyu Sun; Peter C. Burns; Tianbo Liu

doi:10.1002/anie.201601852

Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages: An Inorganic Mimic of K⁺Ion Channels

Yunyi Gao
, Jennifer E.S. Szymanowski
, Xinyu Sun
, Peter C. Burns
, Tianbo Liu

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

An actinyl peroxide cage cluster, Li_48+mK₁₂(OH)_m[UO₂(O₂)(OH)]₆₀(H₂O)_n(m≈20 and n≈310; U₆₀), discriminates precisely between Na⁺and K⁺ions when heated to certain temperatures, a most essential feature for K⁺selective filters. The U₆₀clusters demonstrate several other features in common with K⁺ion channels, including passive transport of K⁺ions, a high flux rate, and the dehydration of U₆₀and K⁺ions. These qualities make U₆₀(a pure inorganic cluster) a promising ion channel mimic in an aqueous environment. Laser light scattering (LLS) and isothermal titration calorimetry (ITC) studies revealed that the tailorable ion selectivity of U₆₀clusters is a result of the thermal responsiveness of the U₆₀hydration shells. U₆₀clusters demonstrate tunable ion selectivity at different temperatures that can mimic the function of protein ion channels. Adjustable permeability toward different alkali ions is mainly attributed to the thermal responsiveness of the U₆₀cluster's hydration shell thickness.

Original language	English
Pages (from-to)	6887-6891
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	24
DOIs	https://doi.org/10.1002/anie.201601852
State	Published - Jun 6 2016
Externally published	Yes

Funding

This material is based upon work supported by the Materials Science of Actinides Center, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC0001089.

Keywords

ion channels
ion selectivity
self-assembly
uranyl peroxide nanocages

Access to Document

10.1002/anie.201601852

Cite this

@article{36ccf9c9993e4261bb4a80f56c4f1ccc,

title = "Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages: An Inorganic Mimic of K+Ion Channels",

abstract = "An actinyl peroxide cage cluster, Li48+mK12(OH)m[UO2(O2)(OH)]60(H2O)n(m≈20 and n≈310; U60), discriminates precisely between Na+and K+ions when heated to certain temperatures, a most essential feature for K+selective filters. The U60clusters demonstrate several other features in common with K+ion channels, including passive transport of K+ions, a high flux rate, and the dehydration of U60and K+ions. These qualities make U60(a pure inorganic cluster) a promising ion channel mimic in an aqueous environment. Laser light scattering (LLS) and isothermal titration calorimetry (ITC) studies revealed that the tailorable ion selectivity of U60clusters is a result of the thermal responsiveness of the U60hydration shells. U60clusters demonstrate tunable ion selectivity at different temperatures that can mimic the function of protein ion channels. Adjustable permeability toward different alkali ions is mainly attributed to the thermal responsiveness of the U60cluster's hydration shell thickness.",

keywords = "ion channels, ion selectivity, self-assembly, uranyl peroxide nanocages",

author = "Yunyi Gao and Szymanowski, \{Jennifer E.S.\} and Xinyu Sun and Burns, \{Peter C.\} and Tianbo Liu",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2016",

month = jun,

day = "6",

doi = "10.1002/anie.201601852",

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T1 - Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages

T2 - An Inorganic Mimic of K+Ion Channels

AU - Gao, Yunyi

AU - Szymanowski, Jennifer E.S.

AU - Sun, Xinyu

AU - Burns, Peter C.

AU - Liu, Tianbo

PY - 2016/6/6

Y1 - 2016/6/6

N2 - An actinyl peroxide cage cluster, Li48+mK12(OH)m[UO2(O2)(OH)]60(H2O)n(m≈20 and n≈310; U60), discriminates precisely between Na+and K+ions when heated to certain temperatures, a most essential feature for K+selective filters. The U60clusters demonstrate several other features in common with K+ion channels, including passive transport of K+ions, a high flux rate, and the dehydration of U60and K+ions. These qualities make U60(a pure inorganic cluster) a promising ion channel mimic in an aqueous environment. Laser light scattering (LLS) and isothermal titration calorimetry (ITC) studies revealed that the tailorable ion selectivity of U60clusters is a result of the thermal responsiveness of the U60hydration shells. U60clusters demonstrate tunable ion selectivity at different temperatures that can mimic the function of protein ion channels. Adjustable permeability toward different alkali ions is mainly attributed to the thermal responsiveness of the U60cluster's hydration shell thickness.

AB - An actinyl peroxide cage cluster, Li48+mK12(OH)m[UO2(O2)(OH)]60(H2O)n(m≈20 and n≈310; U60), discriminates precisely between Na+and K+ions when heated to certain temperatures, a most essential feature for K+selective filters. The U60clusters demonstrate several other features in common with K+ion channels, including passive transport of K+ions, a high flux rate, and the dehydration of U60and K+ions. These qualities make U60(a pure inorganic cluster) a promising ion channel mimic in an aqueous environment. Laser light scattering (LLS) and isothermal titration calorimetry (ITC) studies revealed that the tailorable ion selectivity of U60clusters is a result of the thermal responsiveness of the U60hydration shells. U60clusters demonstrate tunable ion selectivity at different temperatures that can mimic the function of protein ion channels. Adjustable permeability toward different alkali ions is mainly attributed to the thermal responsiveness of the U60cluster's hydration shell thickness.

KW - ion channels

KW - ion selectivity

KW - self-assembly

KW - uranyl peroxide nanocages

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