The macromolecular neutron diffractometer at the spallation neutron source

Leighton Coates, Brendan Sullivan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

13 Scopus citations

Abstract

The Macromolecular Neutron Diffractometer known as MaNDi is located on beamline 11B of the Spallation Neutron Source at Oak Ridge National Laboratory. Neutrons are produced in discrete pulses at the Spallation Neutron Source, which enables Laue diffraction data through measuring the time-of-flight and thus wavelength of each diffracted neutron. The MaNDi diffractometer is optimized to collect diffraction data from protein crystals with unit cell axes between 30 and 300 Å. The instrument is designed to provide flexibility in several instrumental parameters such as wavelength bandwidth and beam divergence to allow data collection from a range systems. Data collection is possible at room temperature or 100 K using a standard nitrogen gas stream cooler combined with standard X-ray style mounting pins and loops.

Original languageEnglish
Title of host publicationNeutron Crystallography in Structural Biology
PublisherAcademic Press Inc.
Pages87-99
Number of pages13
DOIs
StatePublished - 2020

Publication series

NameMethods in Enzymology
Volume634
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Funding

Research at ORNL's Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy. Research at ORNL's Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy.

FundersFunder number
ORNL's
Office of Basic Energy Sciences
Scientific User Facilities Division
U.S. Department of Energy
Basic Energy Sciences

    Keywords

    • Integration
    • Laue diffraction
    • Neutron crystallography
    • Profile fitting
    • Time-of-flight

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