The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals

Tanushree Ganguly; Benjamin B. Kasten; Dejan Kreimir Buar; Leonard R. MacGillivray; Clifford E. Berkman; Paul D. Benny

doi:10.1039/c1cc15451f

The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)₃ (M = Re, ^99mTc) radiopharmaceuticals

Tanushree Ganguly
, Benjamin B. Kasten
, Dejan Kreimir Buar
, Leonard R. MacGillivray
, Clifford E. Berkman
, Paul D. Benny

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)₃ (M = Re, ^99mTc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.

Original language	English
Pages (from-to)	12846-12848
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	48
DOIs	https://doi.org/10.1039/c1cc15451f
State	Published - Dec 28 2011
Externally published	Yes

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abstract = "Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)3 (M = Re, 99mTc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.",

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AU - Ganguly, Tanushree

AU - Kasten, Benjamin B.

AU - Buar, Dejan Kreimir

AU - MacGillivray, Leonard R.

AU - Berkman, Clifford E.

AU - Benny, Paul D.

PY - 2011/12/28

Y1 - 2011/12/28

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AB - Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)3 (M = Re, 99mTc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.

UR - https://www.scopus.com/pages/publications/82255170599

U2 - 10.1039/c1cc15451f

DO - 10.1039/c1cc15451f

M3 - Article

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AN - SCOPUS:82255170599

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VL - 47

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JO - Chemical Communications

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ER -

The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)₃ (M = Re, ^99mTc) radiopharmaceuticals

Abstract

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