The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals

Tanushree Ganguly, Benjamin B. Kasten, Dejan Kreimir Buar, Leonard R. MacGillivray, Clifford E. Berkman, Paul D. Benny

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)3 (M = Re, 99mTc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.

Original languageEnglish
Pages (from-to)12846-12848
Number of pages3
JournalChemical Communications
Volume47
Issue number48
DOIs
StatePublished - Dec 28 2011
Externally publishedYes

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