TY - JOUR
T1 - The genome of Nanoarchaeum equitans
T2 - Insights into early archaeal evolution and derived parasitism
AU - Waters, Elizabeth
AU - Hohn, Michael J.
AU - Ahel, Ivan
AU - Graham, David E.
AU - Adams, Mark D.
AU - Barnstead, Mary
AU - Beeson, Karen Y.
AU - Bibbs, Lisa
AU - Bolanos, Randall
AU - Keller, Martin
AU - Kretz, Keith
AU - Lin, Xiaoying
AU - Mathur, Eric
AU - Ni, Jingwei
AU - Podar, Mircea
AU - Richardson, Toby
AU - Sutton, Granger G.
AU - Simon, Melvin
AU - Söll, Dieter
AU - Stetter, Karl O.
AU - Short, Jay M.
AU - Noordewier, Michiel
PY - 2003/10/28
Y1 - 2003/10/28
N2 - The hyperthermophile Nanoarchaeum equitans is an obligate symbiont growing in coculture with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based phylogenies place its branching point early in the archaeal lineage, representing the new archaeal kingdom Nanoarchaeota. The N. equitans genome (490,885 base pairs) encodes the machinery for information processing and repair, but lacks genes for lipid, cofactor, amino acid, or nucleotide biosyntheses, It is the smallest microbial genome sequenced to date, and also one of the most compact, with 95% of the DNA predicted to encode proteins or stable RNAs. Its limited biosynthetic and catabolic capacity indicates that N. equitans' symbiotic relationship to Ignicoccus is parasitic, making it the only known archaeal parasite. Unlike the small genomes of bacterial parasites that are undergoing reductive evolution, N. equitans has few pseudogenes or extensive regions of noncoding DNA. This organism represents a basal archaeal lineage and has a highly reduced genome.
AB - The hyperthermophile Nanoarchaeum equitans is an obligate symbiont growing in coculture with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based phylogenies place its branching point early in the archaeal lineage, representing the new archaeal kingdom Nanoarchaeota. The N. equitans genome (490,885 base pairs) encodes the machinery for information processing and repair, but lacks genes for lipid, cofactor, amino acid, or nucleotide biosyntheses, It is the smallest microbial genome sequenced to date, and also one of the most compact, with 95% of the DNA predicted to encode proteins or stable RNAs. Its limited biosynthetic and catabolic capacity indicates that N. equitans' symbiotic relationship to Ignicoccus is parasitic, making it the only known archaeal parasite. Unlike the small genomes of bacterial parasites that are undergoing reductive evolution, N. equitans has few pseudogenes or extensive regions of noncoding DNA. This organism represents a basal archaeal lineage and has a highly reduced genome.
UR - http://www.scopus.com/inward/record.url?scp=0242300069&partnerID=8YFLogxK
U2 - 10.1073/pnas.1735403100
DO - 10.1073/pnas.1735403100
M3 - Article
C2 - 14566062
AN - SCOPUS:0242300069
SN - 0027-8424
VL - 100
SP - 12984
EP - 12988
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 22
ER -