The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography

Janelle E. Bender; Carey E. Floyd; Brian P. Harrawood; Anuj J. Kapadia; Amy C. Sharma; Jonathan L. Jesneck

doi:10.1117/12.652812

The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography

Janelle E. Bender, Carey E. Floyd, Brian P. Harrawood, Anuj J. Kapadia, Amy C. Sharma, Jonathan L. Jesneck

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

Previous research has shown benign and cancerous tissues to have different chemical make-ups. To measure the elemental concentration of biological samples noninvasively, we used neutron stimulated emission computed tomography (NSECT). When an incident neutron scatters inelastically from an atomic nucleus, it emits characteristic gamma energies, allowing for measurement of the elemental concentration of biological samples. Thus NSECT has the potential to be a method for precancerous tissue detection. In Monte Carlo simulations, we bombarded both a benign and a malignant human breast with 50 million neutrons. The resulting photon spectra were blurred to model the detector resolutions and then analyzed for peak detection. This simulation study analyzed the characteristic spectra using three detectors of different resolutions: a High-Purity Germanium (HPGe) semiconductor, a Bismuth Germanate (BGO) scintillator, and a Sodium Iodide (NaI) scintillator. The effective energy resolutions of these detectors are 0.1%, 7%, and 12%, respectively. The detectability of element peaks in the breast model was greatly reduced when the blur increased from just 0.1% to 7%. These initial experiments are valuable in choosing optimal detectors for peak detection in further NSECT studies and indicate that high-resolution detectors, such as HPGe, are required for using spectral peak analysis for breast cancer prediction.

Original language	English
Title of host publication	Medical Imaging 2006
Subtitle of host publication	Physics of Medical Imaging
DOIs	https://doi.org/10.1117/12.652812
State	Published - 2006
Externally published	Yes
Event	Medical Imaging 2006: Physics of Medical Imaging - San Diego, CA, United States Duration: Feb 12 2006 → Feb 16 2006

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6142 III
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2006: Physics of Medical Imaging
Country/Territory	United States
City	San Diego, CA
Period	02/12/06 → 02/16/06

Keywords

Neutrons in Imaging
Novel Methods (OT)
Simulation (SIM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.652812

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Bender, J. E., Floyd, C. E., Harrawood, B. P., Kapadia, A. J., Sharma, A. C., & Jesneck, J. L. (2006). The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography. In Medical Imaging 2006: Physics of Medical Imaging Article 61424Z (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6142 III). https://doi.org/10.1117/12.652812

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title = "The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography",

abstract = "Previous research has shown benign and cancerous tissues to have different chemical make-ups. To measure the elemental concentration of biological samples noninvasively, we used neutron stimulated emission computed tomography (NSECT). When an incident neutron scatters inelastically from an atomic nucleus, it emits characteristic gamma energies, allowing for measurement of the elemental concentration of biological samples. Thus NSECT has the potential to be a method for precancerous tissue detection. In Monte Carlo simulations, we bombarded both a benign and a malignant human breast with 50 million neutrons. The resulting photon spectra were blurred to model the detector resolutions and then analyzed for peak detection. This simulation study analyzed the characteristic spectra using three detectors of different resolutions: a High-Purity Germanium (HPGe) semiconductor, a Bismuth Germanate (BGO) scintillator, and a Sodium Iodide (NaI) scintillator. The effective energy resolutions of these detectors are 0.1%, 7%, and 12%, respectively. The detectability of element peaks in the breast model was greatly reduced when the blur increased from just 0.1% to 7%. These initial experiments are valuable in choosing optimal detectors for peak detection in further NSECT studies and indicate that high-resolution detectors, such as HPGe, are required for using spectral peak analysis for breast cancer prediction.",

keywords = "Neutrons in Imaging, Novel Methods (OT), Simulation (SIM)",

author = "Bender, {Janelle E.} and Floyd, {Carey E.} and Harrawood, {Brian P.} and Kapadia, {Anuj J.} and Sharma, {Amy C.} and Jesneck, {Jonathan L.}",

year = "2006",

doi = "10.1117/12.652812",

language = "English",

isbn = "0819461857",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Medical Imaging 2006",

note = "Medical Imaging 2006: Physics of Medical Imaging ; Conference date: 12-02-2006 Through 16-02-2006",

}

Bender, JE, Floyd, CE, Harrawood, BP, Kapadia, AJ, Sharma, AC & Jesneck, JL 2006, The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography. in Medical Imaging 2006: Physics of Medical Imaging., 61424Z, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6142 III, Medical Imaging 2006: Physics of Medical Imaging, San Diego, CA, United States, 02/12/06. https://doi.org/10.1117/12.652812

The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography. / Bender, Janelle E.; Floyd, Carey E.; Harrawood, Brian P. et al.
Medical Imaging 2006: Physics of Medical Imaging. 2006. 61424Z (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6142 III).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography

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AU - Floyd, Carey E.

AU - Harrawood, Brian P.

AU - Kapadia, Anuj J.

AU - Sharma, Amy C.

AU - Jesneck, Jonathan L.

PY - 2006

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AB - Previous research has shown benign and cancerous tissues to have different chemical make-ups. To measure the elemental concentration of biological samples noninvasively, we used neutron stimulated emission computed tomography (NSECT). When an incident neutron scatters inelastically from an atomic nucleus, it emits characteristic gamma energies, allowing for measurement of the elemental concentration of biological samples. Thus NSECT has the potential to be a method for precancerous tissue detection. In Monte Carlo simulations, we bombarded both a benign and a malignant human breast with 50 million neutrons. The resulting photon spectra were blurred to model the detector resolutions and then analyzed for peak detection. This simulation study analyzed the characteristic spectra using three detectors of different resolutions: a High-Purity Germanium (HPGe) semiconductor, a Bismuth Germanate (BGO) scintillator, and a Sodium Iodide (NaI) scintillator. The effective energy resolutions of these detectors are 0.1%, 7%, and 12%, respectively. The detectability of element peaks in the breast model was greatly reduced when the blur increased from just 0.1% to 7%. These initial experiments are valuable in choosing optimal detectors for peak detection in further NSECT studies and indicate that high-resolution detectors, such as HPGe, are required for using spectral peak analysis for breast cancer prediction.

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KW - Novel Methods (OT)

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M3 - Conference contribution

AN - SCOPUS:33745420211

SN - 0819461857

SN - 9780819461858

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2006

T2 - Medical Imaging 2006: Physics of Medical Imaging

Y2 - 12 February 2006 through 16 February 2006

ER -

The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography

Abstract

Publication series

Conference

Keywords

UN SDGs

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