The distribution of dermal tumorigens in coal liquids: Relationship of tumorigenicity and microbial mutagenicity

J. M. Holland; F. W. Larimer; T. K. Rao; J. L. Epler; C. ‐H Ho; M. V. Buchanan; M. R. Guerin

doi:10.1002/jat.2550040302

The distribution of dermal tumorigens in coal liquids: Relationship of tumorigenicity and microbial mutagenicity

J. M. Holland, F. W. Larimer, T. K. Rao, J. L. Epler, C. ‐H Ho, M. V. Buchanan, M. R. Guerin

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Abstract

Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigencity differ from those responsible for mutagenicity.

Original language	English
Pages (from-to)	117-123
Number of pages	7
Journal	Journal of Applied Toxicology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1002/jat.2550040302
State	Published - Jun 1984

Keywords

Ames test
skin tumorigenicity
synthetic petroleum oil

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title = "The distribution of dermal tumorigens in coal liquids: Relationship of tumorigenicity and microbial mutagenicity",

abstract = "Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigencity differ from those responsible for mutagenicity.",

keywords = "Ames test, skin tumorigenicity, synthetic petroleum oil",

author = "Holland, {J. M.} and Larimer, {F. W.} and Rao, {T. K.} and Epler, {J. L.} and Ho, {C. ‐H} and Buchanan, {M. V.} and Guerin, {M. R.}",

year = "1984",

month = jun,

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T1 - The distribution of dermal tumorigens in coal liquids

T2 - Relationship of tumorigenicity and microbial mutagenicity

AU - Holland, J. M.

AU - Larimer, F. W.

AU - Rao, T. K.

AU - Epler, J. L.

AU - Ho, C. ‐H

AU - Buchanan, M. V.

AU - Guerin, M. R.

PY - 1984/6

Y1 - 1984/6

N2 - Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigencity differ from those responsible for mutagenicity.

AB - Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigencity differ from those responsible for mutagenicity.

KW - Ames test

KW - skin tumorigenicity

KW - synthetic petroleum oil

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U2 - 10.1002/jat.2550040302

DO - 10.1002/jat.2550040302

M3 - Article

C2 - 6379026

AN - SCOPUS:0021145247

SN - 0260-437X

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EP - 123

JO - Journal of Applied Toxicology

JF - Journal of Applied Toxicology

IS - 3

ER -

The distribution of dermal tumorigens in coal liquids: Relationship of tumorigenicity and microbial mutagenicity

Abstract

Keywords

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