The biokinetics of ruthenium in the human body

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Abstract

The International Commission on Radiological Protection (ICRP) is updating its biokinetic and dosimetric models for workers and subsequently will revisit its models for members of the public. This paper summarises the biokinetic database for ruthenium and proposes a new biokinetic model for systemic ruthenium. In contrast to the ICRP's current model, the proposed model depicts recycling of ruthenium between tissues and blood and a non-uniform distribution of systemic ruthenium. The paper also points out inconsistencies between the ICRP's respiratory model for RuO. 4 vapour and reported data, and inconsistencies between the ICRP's default gastrointestinal (GI) uptake value and data for some forms of ruthenium. Dosimetric implications of the proposed systemic model and the findings for inhaled RuO. 4 vapour and GI uptake of ruthenium are examined.

Original languageEnglish
Article numberncr197
Pages (from-to)389-402
Number of pages14
JournalRadiation Protection Dosimetry
Volume148
Issue number4
DOIs
StatePublished - Mar 2012

Funding

This work was supported by the Office of Radiation and Indoor Air, U. S. Environmental Protection Agency (EPA), under Interagency Agreement DOE No. 1824–S581-A1, under contract No. DE-AC05-00OR22725 with UT-Battelle. The manuscript was prepared by Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. Department of Energy under contract DE-AC05-00OR22725. The submitted manuscript has been authored by a contractor of the U.S. Government under contract DE-AC05-00OR22725. Accordingly, the U.S. Government retains a non-exclusive, royalty-free licence to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes.

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