Abstract
We know very little about the metabolic functioning and evolutionary dynamics of microbial communities. Recent advances in comprehensive, sequencing-based methods, however, are laying a molecular foundation for new insights into how microbial communities shape the Earth's biosphere. Here we explore the convergence of microbial ecology, genomics, biological mass spectrometry and informatics that form the new field of microbial community proteogenomics. We discuss the first applications of proteogenomics and its potential for studying the physiology, ecology and evolution of microbial populations and communities.
| Original language | English |
|---|---|
| Pages (from-to) | 196-205 |
| Number of pages | 10 |
| Journal | Nature Reviews Microbiology |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2009 |
Funding
Acknowledgements Funding was provided by the United States Department of Energy: Genomics: Genomes-to-Life Program, the National Science Foundation Biocomplexity Program and the NASA Astrobiology Institute. B. R. Maggard is thanked for secretarial assistance in the preparation of this manuscript. Oak Ridge National Laboratory is managed by University of Tennessee–Battelle LLC for the Department of Energy under contract DOE-AC05-00OR22725.
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