Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer

Charles E. Carraher; Michael R. Roner; Jessica Frank; Alica Moric-Johnson; Lindsey C. Miller; Kendra Black; Paul Slawek; Francesca Mosca; Jeffrey D. Einkauf; Floyd Russell

doi:10.3390/pr5030050

Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer

Charles E. Carraher
, Michael R. Roner
, Jessica Frank
, Alica Moric-Johnson
, Lindsey C. Miller
, Kendra Black
, Paul Slawek
, Francesca Mosca
, Jeffrey D. Einkauf
, Floyd Russell

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.

Original language	English
Article number	50
Journal	Processes
Volume	5
Issue number	3
DOIs	https://doi.org/10.3390/pr5030050
State	Published - Sep 1 2017
Externally published	Yes

Keywords

Anticancer
Breast cancer
Group 4 metallocene polymers
Group 4 metallocenes
Interfacial polycondensation
Organotin polyethers
Pancreatic cancer
Poly(ethylene glycol)
Prostate cancer

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10.3390/pr5030050

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title = "Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer",

abstract = "Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.",

keywords = "Anticancer, Breast cancer, Group 4 metallocene polymers, Group 4 metallocenes, Interfacial polycondensation, Organotin polyethers, Pancreatic cancer, Poly(ethylene glycol), Prostate cancer",

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month = sep,

day = "1",

doi = "10.3390/pr5030050",

language = "English",

volume = "5",

journal = "Processes",

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TY - JOUR

T1 - Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer

AU - Carraher, Charles E.

AU - Roner, Michael R.

AU - Frank, Jessica

AU - Moric-Johnson, Alica

AU - Miller, Lindsey C.

AU - Black, Kendra

AU - Slawek, Paul

AU - Mosca, Francesca

AU - Einkauf, Jeffrey D.

AU - Russell, Floyd

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.

AB - Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.

KW - Anticancer

KW - Breast cancer

KW - Group 4 metallocene polymers

KW - Group 4 metallocenes

KW - Interfacial polycondensation

KW - Organotin polyethers

KW - Pancreatic cancer

KW - Poly(ethylene glycol)

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/85034243803

U2 - 10.3390/pr5030050

DO - 10.3390/pr5030050

M3 - Article

AN - SCOPUS:85034243803

SN - 2227-9717

VL - 5

JO - Processes

JF - Processes

IS - 3

M1 - 50

ER -

Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer

Abstract

Keywords

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