Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer

Charles E. Carraher, Michael R. Roner, Jessica Frank, Alica Moric-Johnson, Lindsey C. Miller, Kendra Black, Paul Slawek, Francesca Mosca, Jeffrey D. Einkauf, Floyd Russell

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.

Original languageEnglish
Article number50
JournalProcesses
Volume5
Issue number3
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Keywords

  • Anticancer
  • Breast cancer
  • Group 4 metallocene polymers
  • Group 4 metallocenes
  • Interfacial polycondensation
  • Organotin polyethers
  • Pancreatic cancer
  • Poly(ethylene glycol)
  • Prostate cancer

Fingerprint

Dive into the research topics of 'Synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer'. Together they form a unique fingerprint.

Cite this