Abstract
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.
Original language | English |
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Article number | 50 |
Journal | Processes |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1 2017 |
Externally published | Yes |
Keywords
- Anticancer
- Breast cancer
- Group 4 metallocene polymers
- Group 4 metallocenes
- Interfacial polycondensation
- Organotin polyethers
- Pancreatic cancer
- Poly(ethylene glycol)
- Prostate cancer