Synthesis of reversible shell cross-linked micelles for controlled release of bioactive agents

SCL micelles formed with cystamine, a reversible cross-linking agent, was analyzed. The individual copolymer chains produced after cleavage of the disulfide bonds in the cystamine linkages can be reassembled into micelles and subsequently re-cross-linked, this was also analyzed. Triblock copolymer micelles were prepared from a novel thermoresponsive ABC triblock copolymer that self-assembles in aqueous solution. The rate of drug release can be easily controlled from these SCL micelles, demonstrating their potential as nanoscale drug delivery vehicles.