Synthesis of N1-tritylethane-1,1,2,2-d4-1,2-diamine: A novel mono-protected C-deuterated ethylenediamine synthon

Jun Yang; Kunlun Hong; Peter V. Bonnesen

doi:10.1002/jlcr.2977

Synthesis of N¹-tritylethane-1,1,2,2-d₄-1,2-diamine: A novel mono-protected C-deuterated ethylenediamine synthon

Jun Yang
, Kunlun Hong
, Peter V. Bonnesen

Macromolecular Nanomaterials

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A convenient and high-yield synthesis for N¹-tritylethane-1,1,2, 2-d₄-1,2-diamine, a novel mono-protected ethylenediamine-C-d ₄, is reported. N¹-tritylethane-1,1,2,2-d ₄-1,2-diamine was prepared in three steps from ethylene oxide-d ₄ in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d₄ in two steps from 1,2-dibromoethane-d₄ in a combined yield in the range 61-65%.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	55
Issue number	13
DOIs	https://doi.org/10.1002/jlcr.2977
State	Published - Nov 2012

Keywords

deuterated ethylenediamine

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title = "Synthesis of N1-tritylethane-1,1,2,2-d4-1,2-diamine: A novel mono-protected C-deuterated ethylenediamine synthon",

abstract = "A convenient and high-yield synthesis for N1-tritylethane-1,1,2, 2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d 4, is reported. N1-tritylethane-1,1,2,2-d 4-1,2-diamine was prepared in three steps from ethylene oxide-d 4 in a combined yield in the range 68-76\%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65\%.",

keywords = "deuterated ethylenediamine",

author = "Jun Yang and Kunlun Hong and Bonnesen, \{Peter V.\}",

year = "2012",

month = nov,

doi = "10.1002/jlcr.2977",

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volume = "55",

pages = "463--466",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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TY - JOUR

T1 - Synthesis of N1-tritylethane-1,1,2,2-d4-1,2-diamine

T2 - A novel mono-protected C-deuterated ethylenediamine synthon

AU - Yang, Jun

AU - Hong, Kunlun

AU - Bonnesen, Peter V.

PY - 2012/11

Y1 - 2012/11

N2 - A convenient and high-yield synthesis for N1-tritylethane-1,1,2, 2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d 4, is reported. N1-tritylethane-1,1,2,2-d 4-1,2-diamine was prepared in three steps from ethylene oxide-d 4 in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65%.

AB - A convenient and high-yield synthesis for N1-tritylethane-1,1,2, 2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d 4, is reported. N1-tritylethane-1,1,2,2-d 4-1,2-diamine was prepared in three steps from ethylene oxide-d 4 in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65%.

KW - deuterated ethylenediamine

UR - https://www.scopus.com/pages/publications/84870156969

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DO - 10.1002/jlcr.2977

M3 - Article

AN - SCOPUS:84870156969

SN - 0362-4803

VL - 55

SP - 463

EP - 466

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 13

ER -

Synthesis of N¹-tritylethane-1,1,2,2-d₄-1,2-diamine: A novel mono-protected C-deuterated ethylenediamine synthon

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