TY - JOUR
T1 - Synthesis of N1-tritylethane-1,1,2,2-d4-1,2-diamine
T2 - A novel mono-protected C-deuterated ethylenediamine synthon
AU - Yang, Jun
AU - Hong, Kunlun
AU - Bonnesen, Peter V.
PY - 2012/11
Y1 - 2012/11
N2 - A convenient and high-yield synthesis for N1-tritylethane-1,1,2, 2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d 4, is reported. N1-tritylethane-1,1,2,2-d 4-1,2-diamine was prepared in three steps from ethylene oxide-d 4 in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65%.
AB - A convenient and high-yield synthesis for N1-tritylethane-1,1,2, 2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d 4, is reported. N1-tritylethane-1,1,2,2-d 4-1,2-diamine was prepared in three steps from ethylene oxide-d 4 in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65%.
KW - deuterated ethylenediamine
UR - http://www.scopus.com/inward/record.url?scp=84870156969&partnerID=8YFLogxK
U2 - 10.1002/jlcr.2977
DO - 10.1002/jlcr.2977
M3 - Article
AN - SCOPUS:84870156969
SN - 0362-4803
VL - 55
SP - 463
EP - 466
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
IS - 13
ER -