Synthesis of N-halamine-functionalized silica-polymer core-shell nanoparticles and their enhanced antibacterial activity

Alideertu Dong, Jinfeng Huang, Shi Lan, Tao Wang, Linghan Xiao, Weiwei Wang, Tianyi Zhao, Xin Zheng, Fengqi Liu, Ge Gao, Yuxin Chen

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

N-halamine-functionalized silica-polymer core-shell nanoparticles with enhanced antibacterial activity were synthesized through the encapsulation of silica nanoparticles as support with polymeric N-halamine. The as-synthesized nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive x-ray spectrometry (EDX), dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared (FTIR). These N-halamine-functionalized silica-polymer core-shell nanoparticles displayed powerful antibacterial performance against both Gram-positive bacteria and Gram-negative bacteria, and their antibacterial activities have been greatly improved compared with their bulk counterparts. Therefore, these N-halamine-functionalized silica-polymer core-shell nanoparticles have the potential for various significant applications such as in medical devices, healthcare products, water purification systems, hospitals, dental office equipment, food packaging, food storage, household sanitation, etc.

Original languageEnglish
Article number295602
JournalNanotechnology
Volume22
Issue number29
DOIs
StatePublished - Jul 22 2011
Externally publishedYes

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