Synthesis and Structural and Initial Cancer Cell Line Characterization of Organotin Polyesters from Dipicolinic Acid

Charles E. Carraher, Paul P. Slawek, Michael R. Roner, Alisa Moric-Johnson, Lindsey C. Miller, Jeffrey D. Einkauf, Floyd Russell

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The interfacial polymerization is employed to produce high polymer poly(ester ethers) from the reaction of the salt of dipicolinic acid and various organotin dihalides. They are rapidly synthesized with yield increasing as the length of the organotin alkyl chain increases. Infrared spectroscopy shows the formation of new bands derived from the Sn–O and Sn–O(CO) linkages. IR also shows that the products exist as a combination of molecular geometries about the tin atom. MALDI MS shows formation of ion fragment clusters to five and six units in length. The products show good inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines.

Original languageEnglish
Pages (from-to)1338-1350
Number of pages13
JournalJournal of Inorganic and Organometallic Polymers and Materials
Volume26
Issue number6
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • Anthrax
  • Biological warfare
  • Breast cancer
  • Dipicolinic acid
  • Interfacial polymerization
  • MALDI MS
  • Organotin polyesters
  • Organotin polymers
  • Pancreatic cancer

Fingerprint

Dive into the research topics of 'Synthesis and Structural and Initial Cancer Cell Line Characterization of Organotin Polyesters from Dipicolinic Acid'. Together they form a unique fingerprint.

Cite this