Abstract
Lanthanide phosphate nanomaterials are appealing as multifunctional platforms for biomedical applications because of their low toxicity, radiation resistance, and unique luminescence and magnetic properties. Lanthanide phosphate nanoparticles (NPs) radiolabeled with 156Eu were synthesized by an aqueous route using sodium tripolyphosphate as a phosphate source and complexing agent. GdPO4 was used as a host matrix, while synthetic concentrations of Ce3+/Tb3+ and Eu3+ were varied between 5–40% and 10–30%, respectively, and yielded spherical NPs with hexagonal crystal system and particle size < 5 nm. Luminescence emission and magnetic susceptibility were influenced by lanthanide concentrations where characteristic 5D0-7FJ and 5D4-7FJ transitions were observed for Eu3+- and Tb3+-doped NPs, respectively. Chemical yield of > 90% was achieved for GdPO4 and Gd0.6Ce0.3Tb0.1PO4 NPs intrinsically radiolabeled with 156Eu. In vitro retention of 156Eu within LnPO4 NPs was > 97% over 3 weeks. Intrinsically radiolabeled LnPO4 NPs have the potential to combine the luminescence and magnetic properties of Ln3+ ions with lanthanide radioisotopes for biomedical and environmental applications. [Figure not available: see fulltext.].
Original language | English |
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Article number | 238 |
Journal | Journal of Nanoparticle Research |
Volume | 20 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2018 |
Funding
Acknowledgments This work was financed by the Virginia Commonwealth University (VCU) with the support of the Mechanical and Nuclear Engineering Department and NRC-HQ-84-14-FOA-002, Faculty Development Program in Radiation Detection and Health Physics at VCU. Work at ORNL supported in part by the Isotope Production/Distribution Program, Office of Nuclear Physics of the US Department of Energy. We would like to thank the staff of Nuclear and Radiochemistry Group at ORNL for providing Eu isotopes and general help with radiochemistry and radioactivity measurement. The authors also wish to thank the staff at the Nanomaterials Core Characterization Facility in the VCU School of Engineering and the Instrumentation Laboratory in the Department of Chemistry at VCU for their assistance. Notice: This manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan). This work was financed by the Virginia Commonwealth University (VCU) with the support of the Mechanical and Nuclear Engineering Department and NRC-HQ-84-14-FOA-002, Faculty Development Program in Radiation Detection and Health Physics at VCU. Work at ORNL supported in part by the Isotope Production/Distribution Program, Office of Nuclear Physics of the US Department of Energy. We would like to thank the staff of Nuclear and Radiochemistry Group at ORNL for providing Eu isotopes and general help with radiochemistry and radioactivity measurement. The authors also wish to thank the staff at the Nanomaterials Core Characterization Facility in the VCU School of Engineering and the Instrumentation Laboratory in the Department of Chemistry at VCU for their assistance. Notice: This manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan). The authors declare that they have no conflict of interest.
Keywords
- Europium-156
- Intrinsically radiolabeled nanoparticles
- Lanthanide phosphate
- Luminescence
- Magnetic susceptibility
- Multifunctional nanomaterials
- Nanobiomedicine