TY - JOUR
T1 - Synthesis and Characterization, Including Cancer Cell Line Inhibition, of Group VA (Group 15)-Containing Polyesters from Reaction with Camphoric Acid
AU - Carraher, Charles E.
AU - Roner, Michael R.
AU - Mosca, Francesca
AU - Moric-Johnson, Alisa
AU - Miller, Lindsey C.
AU - Einkauf, Jeffrey D.
AU - Russell, Floyd
AU - Slawek, Paul
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS and proton NMR are consistent with the formation of the polyester structure. Ion fragment clusters to four to six units are identified. The polymers show good inhibition of a group of cancer cell lines including two pancreatic human cancer cell lines. In comparison with other metal/camphoric acid polymers, the metallocene polymers exhibit low EC50 to the nanogram/ml range, and CI50 values greater than one thousand for the hafnocene and zirconocene products. If this trend continues, the emphasis should be on the Group IVB metallocenes with respect to efforts to create anticancer drugs.
AB - Polyesters were rapidly synthesized employing interfacial polymerization from reaction of the salt of camphoric acid with Group VA (Group 15) triphenylmetallic dihalides. Yields range from 25 to 46 percent with chain lengths about 250. Infrared spectroscopy shows the formation of two new bands one assigned to the symmetrical M–O stretching and the second assigned to the asymmetrical M–O stretching. The bridging structure about the metal atom increases as the metal atom size increases. MALDI MS and proton NMR are consistent with the formation of the polyester structure. Ion fragment clusters to four to six units are identified. The polymers show good inhibition of a group of cancer cell lines including two pancreatic human cancer cell lines. In comparison with other metal/camphoric acid polymers, the metallocene polymers exhibit low EC50 to the nanogram/ml range, and CI50 values greater than one thousand for the hafnocene and zirconocene products. If this trend continues, the emphasis should be on the Group IVB metallocenes with respect to efforts to create anticancer drugs.
KW - Antimony-containing polymers
KW - Arsenic-containing polymers
KW - Bismuth-containing polymers
KW - Breast cancer
KW - Group 15 metal-containing polymers
KW - MALDI MS
KW - Pancreatic cancer
KW - VA metal containing polymers
UR - http://www.scopus.com/inward/record.url?scp=85023169410&partnerID=8YFLogxK
U2 - 10.1007/s10904-017-0622-9
DO - 10.1007/s10904-017-0622-9
M3 - Article
AN - SCOPUS:85023169410
SN - 1574-1443
VL - 27
SP - 1627
EP - 1639
JO - Journal of Inorganic and Organometallic Polymers and Materials
JF - Journal of Inorganic and Organometallic Polymers and Materials
IS - 6
ER -