Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds

Andrew R. Burgoyne; Catherine H. Kaschula; M. Iqbal Parker; Gregory S. Smith

doi:10.1016/j.jorganchem.2017.05.058

Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds

Andrew R. Burgoyne, Catherine H. Kaschula, M. Iqbal Parker, Gregory S. Smith

Medical Isotopes and Development

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Mononuclear and trinuclear half-sandwich Rh(III) and Ir(III) complexes based on a sulfonated scaffold have been synthesised and characterised using NMR and IR spectroscopy, mass spectrometry and elemental analysis. The cytotoxicities of the compounds were evaluated against the WHC01 oesophageal cancer cell line, with a slight increase in activity observed upon coordination of the metal.

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	Journal of Organometallic Chemistry
Volume	846
DOIs	https://doi.org/10.1016/j.jorganchem.2017.05.058
State	Published - 2017

Funding

Financial support from the University of Cape Town and the National Research Foundation (NRF) of South Africa (Grant Numbers: 90500 and 107856) is gratefully acknowledged.

Keywords

Antitumour agents
Bioorganometallic chemistry
Half-sandwich complexes
Iridium(III)
Rhodium(III)
Sulfonates

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10.1016/j.jorganchem.2017.05.058

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@article{44b7c029cda94dc98b9bfbc20c7095ab,

title = "Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds",

abstract = "Mononuclear and trinuclear half-sandwich Rh(III) and Ir(III) complexes based on a sulfonated scaffold have been synthesised and characterised using NMR and IR spectroscopy, mass spectrometry and elemental analysis. The cytotoxicities of the compounds were evaluated against the WHC01 oesophageal cancer cell line, with a slight increase in activity observed upon coordination of the metal.",

keywords = "Antitumour agents, Bioorganometallic chemistry, Half-sandwich complexes, Iridium(III), Rhodium(III), Sulfonates",

author = "Burgoyne, \{Andrew R.\} and Kaschula, \{Catherine H.\} and Parker, \{M. Iqbal\} and Smith, \{Gregory S.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

doi = "10.1016/j.jorganchem.2017.05.058",

language = "English",

volume = "846",

pages = "100--104",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier",

}

Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds. / Burgoyne, Andrew R.; Kaschula, Catherine H.; Parker, M. Iqbal et al.
In: Journal of Organometallic Chemistry, Vol. 846, 2017, p. 100-104.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds

AU - Burgoyne, Andrew R.

AU - Kaschula, Catherine H.

AU - Parker, M. Iqbal

AU - Smith, Gregory S.

PY - 2017

Y1 - 2017

N2 - Mononuclear and trinuclear half-sandwich Rh(III) and Ir(III) complexes based on a sulfonated scaffold have been synthesised and characterised using NMR and IR spectroscopy, mass spectrometry and elemental analysis. The cytotoxicities of the compounds were evaluated against the WHC01 oesophageal cancer cell line, with a slight increase in activity observed upon coordination of the metal.

AB - Mononuclear and trinuclear half-sandwich Rh(III) and Ir(III) complexes based on a sulfonated scaffold have been synthesised and characterised using NMR and IR spectroscopy, mass spectrometry and elemental analysis. The cytotoxicities of the compounds were evaluated against the WHC01 oesophageal cancer cell line, with a slight increase in activity observed upon coordination of the metal.

KW - Antitumour agents

KW - Bioorganometallic chemistry

KW - Half-sandwich complexes

KW - Iridium(III)

KW - Rhodium(III)

KW - Sulfonates

UR - https://www.scopus.com/pages/publications/85020317423

U2 - 10.1016/j.jorganchem.2017.05.058

DO - 10.1016/j.jorganchem.2017.05.058

M3 - Article

AN - SCOPUS:85020317423

SN - 0022-328X

VL - 846

SP - 100

EP - 104

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

ER -

Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds

Abstract

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Keywords

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