Surface stabilization of diblock PEG-PLGA micelles by polymerization of N-vinyl-2-pyrrolidone

Hong Kee Kim; Tae Gwan Park

doi:10.1002/1521-3927(20020101)23:1<26::AID-MARC26>3.0.CO;2-I

Surface stabilization of diblock PEG-PLGA micelles by polymerization of N-vinyl-2-pyrrolidone

Hong Kee Kim, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This paper presents a new approach to improving the physical stability of biodegradable poly(ethylene glycol)-block-poly[(DL-lactic acid)-co-(glycolic acid)] (PEG-PLGA), micelles. A hydroxyl-terminated PEG monomethacrylate (PEGmer) macroinitiator was used to prepare a methacrylate-end-capped PEG-PLGA diblock copolymer by the ring-opening polymerization of D,L-lactide and glycolide. The surface-exposed methacrylate groups in the shell layer of the micelles can be polymerized with N-vinyl-2-pyrrolidone. The resulting micelles show substantially enhanced stability.

Original language	English
Pages (from-to)	26-31
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	23
Issue number	1
DOIs	https://doi.org/10.1002/1521-3927(20020101)23:1<26::AID-MARC26>3.0.CO;2-I
State	Published - Jan 9 2002
Externally published	Yes

Keywords

Biodegradable
Micelles
PEG
PLGA

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10.1002/1521-3927(20020101)23:1<26::AID-MARC26>3.0.CO;2-I

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abstract = "This paper presents a new approach to improving the physical stability of biodegradable poly(ethylene glycol)-block-poly[(DL-lactic acid)-co-(glycolic acid)] (PEG-PLGA), micelles. A hydroxyl-terminated PEG monomethacrylate (PEGmer) macroinitiator was used to prepare a methacrylate-end-capped PEG-PLGA diblock copolymer by the ring-opening polymerization of D,L-lactide and glycolide. The surface-exposed methacrylate groups in the shell layer of the micelles can be polymerized with N-vinyl-2-pyrrolidone. The resulting micelles show substantially enhanced stability.",

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N2 - This paper presents a new approach to improving the physical stability of biodegradable poly(ethylene glycol)-block-poly[(DL-lactic acid)-co-(glycolic acid)] (PEG-PLGA), micelles. A hydroxyl-terminated PEG monomethacrylate (PEGmer) macroinitiator was used to prepare a methacrylate-end-capped PEG-PLGA diblock copolymer by the ring-opening polymerization of D,L-lactide and glycolide. The surface-exposed methacrylate groups in the shell layer of the micelles can be polymerized with N-vinyl-2-pyrrolidone. The resulting micelles show substantially enhanced stability.

AB - This paper presents a new approach to improving the physical stability of biodegradable poly(ethylene glycol)-block-poly[(DL-lactic acid)-co-(glycolic acid)] (PEG-PLGA), micelles. A hydroxyl-terminated PEG monomethacrylate (PEGmer) macroinitiator was used to prepare a methacrylate-end-capped PEG-PLGA diblock copolymer by the ring-opening polymerization of D,L-lactide and glycolide. The surface-exposed methacrylate groups in the shell layer of the micelles can be polymerized with N-vinyl-2-pyrrolidone. The resulting micelles show substantially enhanced stability.

KW - Biodegradable

KW - Micelles

KW - PEG

KW - PLGA

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M3 - Article

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JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 1

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Surface stabilization of diblock PEG-PLGA micelles by polymerization of N-vinyl-2-pyrrolidone

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Keywords

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