Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging

Ki Hyun Bae, Kyuri Lee, Chunsoo Kim, Tae Gwan Park

Research output: Contribution to journalArticlepeer-review

173 Scopus citations

Abstract

Multifunctional hollow manganese oxide nanoparticles (HMON) were produced by a bio-inspired surface functionalization approach, using 3,4-dihydroxy-l-phenylalanine (DOPA) as an adhesive moiety, for cancer targeted delivery of therapeutic siRNA and simultaneous diagnosis via magnetic resonance imaging (MRI). Cationic polyethylenimine-DOPA conjugates were stably immobilized onto the surface of HMON due to the strong binding affinity of DOPA to metal oxides, as examined by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. These nanoparticles were subsequently functionalized with a therapeutic monoclonal antibody, Herceptin, to selectively target cancer cells. Confocal microscopy and MR imaging studies revealed that the surface functionalized HMON enabled the targeted detection of cancer cells in T1-weighted MRI as well as the efficient intracellular delivery of siRNA for cell-specific gene silencing. These nanomaterials are expected to be widely exploited as multifunctional delivery vehicles for cancer therapy and imaging applications.

Original languageEnglish
Pages (from-to)176-184
Number of pages9
JournalBiomaterials
Volume32
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Funding

This research was supported by the Ministry for Health, Welfare and Family Affairs, and the World Class University project, Basic Science Research Program (2010-0027955), and the National Research Laboratory program from the Ministry of Education, Science and Technology, Republic of Korea. We would like to thank Jaewon Lee and Prof. Jung Hee Lee in Samsung Medical Center for the synthesis of HMON nanoparticles and MR imaging studies.

Keywords

  • Bio-inspired
  • Magnetic resonance imaging
  • Manganese oxide
  • Nanoparticles
  • Small interfering RNA

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