TY - JOUR
T1 - Suggested reference values for regional blood volumes in children and adolescents
AU - Wayson, Michael B.
AU - Leggett, Richard W.
AU - Jokisch, Derek W.
AU - Lee, Choonsik
AU - Schwarz, Bryan C.
AU - Godwin, William J.
AU - Bolch, Wesley E.
N1 - Publisher Copyright:
© 2018 Institute of Physics and Engineering in Medicine.
PY - 2018/8/6
Y1 - 2018/8/6
N2 - Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present study is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.
AB - Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present study is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.
KW - pediatric blood volumes
KW - reference individuals
KW - regional blood distribution
UR - http://www.scopus.com/inward/record.url?scp=85051459033&partnerID=8YFLogxK
U2 - 10.1088/1361-6560/aad313
DO - 10.1088/1361-6560/aad313
M3 - Article
C2 - 29999494
AN - SCOPUS:85051459033
SN - 0031-9155
VL - 63
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 15
M1 - 155022
ER -