Suggested reference values for regional blood volumes in children and adolescents

Michael B. Wayson; Richard W. Leggett; Derek W. Jokisch; Choonsik Lee; Bryan C. Schwarz; William J. Godwin; Wesley E. Bolch

doi:10.1088/1361-6560/aad313

Suggested reference values for regional blood volumes in children and adolescents

Michael B. Wayson, Richard W. Leggett, Derek W. Jokisch, Choonsik Lee, Bryan C. Schwarz, William J. Godwin, Wesley E. Bolch

Environmental Risk and Energy Analysis

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present study is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.

Original language	English
Article number	155022
Journal	Physics in Medicine and Biology
Volume	63
Issue number	15
DOIs	https://doi.org/10.1088/1361-6560/aad313
State	Published - Aug 6 2018

Funding

This work was supported in part by NCI Grant R01 CA116743, NIBIB Grant R01 EB013558, and EPA/ORNL Contract DE-AC05-000A22725.

Funders	Funder number
EPA/ORNL	DE-AC05-000A22725
National Cancer Institute	R01 CA116743
National Institute of Biomedical Imaging and Bioengineering	R01EB013558
National Computational Infrastructure

Keywords

pediatric blood volumes
reference individuals
regional blood distribution

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10.1088/1361-6560/aad313

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title = "Suggested reference values for regional blood volumes in children and adolescents",

abstract = "Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present study is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.",

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AU - Godwin, William J.

AU - Bolch, Wesley E.

PY - 2018/8/6

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N2 - Estimates of regional blood volumes (BVs) in humans are needed in dosimetric models of radionuclides and radiopharmaceuticals that decay in the circulation to a significant extent. These values are also needed to refine models of tissue elemental composition in computational human phantoms of both patients and exposed members of the general public. The International Commission on Radiological Protection (ICRP) in its Publication 89 provides reference values for total blood content in the full series of their reference individuals, to include the male and female newborn, 1 year-old, 5 year-old, 10 year-old, 15 year-old, and adult. Furthermore, Publication 89 provides reference values for the percentage distribution of total blood volume in 27 different blood-filled organs and tissues of the reference adult male and adult female. However, no similar distribution values are provided for non-adults. The goal of the present study is to present a volumetric scaling methodology to derive these values for the same organs and tissues at ages younger than the reference adult. Literature data on organ-specific vascular growth in the brain, kidneys, and skeletal tissues are also considered.

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Suggested reference values for regional blood volumes in children and adolescents

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Keywords

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