Substrate-independent layer-by-layer assembly by using mussel-adhesive- inspired polymers

Haeshin Lee; Yuhan Lee; Andrea R. Statz; Junsung Rho; Tae Gwan Park; Phillip B. Messersmith

doi:10.1002/adma.200702378

Substrate-independent layer-by-layer assembly by using mussel-adhesive- inspired polymers

Haeshin Lee, Yuhan Lee, Andrea R. Statz, Junsung Rho, Tae Gwan Park, Phillip B. Messersmith

Research output: Contribution to journal › Article › peer-review

412 Scopus citations

Abstract

A study was conducted to demonstrate that a synthetic catecholamine polymer, influenced by by mussel adhesive protein absorbs to all surfaces and can serve as a platform for layer-by-layer (LbL) assembly in a surface-independent manner. Poly(ethylenimine) (PEI), a cationic polymer, was conjugated with 3-(3,4-dihydroxyphenyl)propionic acid, to make catechol-functionalized PEI (PEI-C). It was observed that the degree of catechol modification in PEI-C is 63%, as determined by the ninhydrin test, preserving the cationic character of the polymer for use in LbL, while mimicking the high catechol content of mussel adhesive proteins at the same time. The study also demonstrated that hyaluronic acid (HA), a linear polysaccharide, was selected for an anionic polymer.

Original language	English
Pages (from-to)	1619-1623
Number of pages	5
Journal	Advanced Materials
Volume	20
Issue number	9
DOIs	https://doi.org/10.1002/adma.200702378
State	Published - May 5 2008
Externally published	Yes

Funding

Funders	Funder number
National Institute of Dental and Craniofacial Research	R37DE014193

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10.1002/adma.200702378

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title = "Substrate-independent layer-by-layer assembly by using mussel-adhesive- inspired polymers",

abstract = "A study was conducted to demonstrate that a synthetic catecholamine polymer, influenced by by mussel adhesive protein absorbs to all surfaces and can serve as a platform for layer-by-layer (LbL) assembly in a surface-independent manner. Poly(ethylenimine) (PEI), a cationic polymer, was conjugated with 3-(3,4-dihydroxyphenyl)propionic acid, to make catechol-functionalized PEI (PEI-C). It was observed that the degree of catechol modification in PEI-C is 63%, as determined by the ninhydrin test, preserving the cationic character of the polymer for use in LbL, while mimicking the high catechol content of mussel adhesive proteins at the same time. The study also demonstrated that hyaluronic acid (HA), a linear polysaccharide, was selected for an anionic polymer.",

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AU - Lee, Haeshin

AU - Lee, Yuhan

AU - Statz, Andrea R.

AU - Rho, Junsung

AU - Park, Tae Gwan

AU - Messersmith, Phillip B.

PY - 2008/5/5

Y1 - 2008/5/5

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AB - A study was conducted to demonstrate that a synthetic catecholamine polymer, influenced by by mussel adhesive protein absorbs to all surfaces and can serve as a platform for layer-by-layer (LbL) assembly in a surface-independent manner. Poly(ethylenimine) (PEI), a cationic polymer, was conjugated with 3-(3,4-dihydroxyphenyl)propionic acid, to make catechol-functionalized PEI (PEI-C). It was observed that the degree of catechol modification in PEI-C is 63%, as determined by the ninhydrin test, preserving the cationic character of the polymer for use in LbL, while mimicking the high catechol content of mussel adhesive proteins at the same time. The study also demonstrated that hyaluronic acid (HA), a linear polysaccharide, was selected for an anionic polymer.

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Substrate-independent layer-by-layer assembly by using mussel-adhesive- inspired polymers

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