Stimuli-responsive block copolymers by RAFT and their micellization behavior

Here, we review our recent progress in the synthesis of thermally responsive block copolymers by reversible addition-fragmentation chain transfer polymerization. In aqueous solution at room temperature these block copolymer chains exist as unimers but form micelles when the solution temperature is raised above the lower critical solution temperature. Incorporation of an active monomer Nacryloxysuccinimide into the triblock copolymer allows for facile formation of uniform shell cross-linked micelles by reaction with ethylenediamine in aqueous media. When cystamine was used as the crosslinker, the cross-linking process is fully reversible: the cleaved SCL micelles can be reformed using cystamine as a thiol-exchange compound. These SCL micelles can be used as potential nanoscale drug delivery carriers, and the rate of drug release can be easily controlled.