TY - JOUR
T1 - Stepping on the Gas to a Circular Economy
T2 - Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation
AU - Fackler, Nick
AU - Heijstra, Bjodiern D.
AU - Rasor, Blake J.
AU - Brown, Hunter
AU - Martin, Jacob
AU - Ni, Zhuofu
AU - Shebek, Kevin M.
AU - Rosin, Rick R.
AU - Simpson, Seacutean D.
AU - Tyo, Keith E.
AU - Giannone, Richard J.
AU - Hettich, Robert L.
AU - Tschaplinski, Timothy J.
AU - Leang, Ching
AU - Brown, Steven D.
AU - Jewett, Michael C.
AU - Kodiepke, Michael
N1 - Publisher Copyright:
© 2021 by Annual Reviews. All rights reserved.
PY - 2021/6/7
Y1 - 2021/6/7
N2 - Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change poses significant environmental, economic, and social challenges globally. Technologies that enable carbon capture and conversion of greenhouse gases into useful products will help mitigate climate change by enabling a new circular carbon economy. Gas fermentation usingcarbon-fixing microorganisms offers an economically viable and scalable solution with unique feedstock and product flexibility that has been commercialized recently. We review the state of the art of gas fermentation and discuss opportunities to accelerate future development and rollout. We discuss the current commercial process for conversion of waste gases to ethanol, including the underlying biology, challenges in process scale-up, and progress on genetic tool development and metabolic engineering to expand the product spectrum. We emphasize key enabling technologies to accelerate strain development for acetogens and other nonmodel organisms.
AB - Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change poses significant environmental, economic, and social challenges globally. Technologies that enable carbon capture and conversion of greenhouse gases into useful products will help mitigate climate change by enabling a new circular carbon economy. Gas fermentation usingcarbon-fixing microorganisms offers an economically viable and scalable solution with unique feedstock and product flexibility that has been commercialized recently. We review the state of the art of gas fermentation and discuss opportunities to accelerate future development and rollout. We discuss the current commercial process for conversion of waste gases to ethanol, including the underlying biology, challenges in process scale-up, and progress on genetic tool development and metabolic engineering to expand the product spectrum. We emphasize key enabling technologies to accelerate strain development for acetogens and other nonmodel organisms.
UR - http://www.scopus.com/inward/record.url?scp=85108021226&partnerID=8YFLogxK
U2 - 10.1146/annurev-chembioeng-120120-021122
DO - 10.1146/annurev-chembioeng-120120-021122
M3 - Review article
C2 - 33872517
AN - SCOPUS:85108021226
SN - 1947-5438
VL - 12
SP - 439
EP - 470
JO - Annual Review of Chemical and Biomolecular Engineering
JF - Annual Review of Chemical and Biomolecular Engineering
ER -
