@article{c1d884dbfbe44ac491e84c83963eafdc,
title = "Stable inhibitory activity of regulatory T cells requires the transcription factor Helios",
abstract = "The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid autoimmunity.We report that impaired expression of the transcription factor (TF) Helios by FoxP3+ CD4 and Qa-1{\^a}€{"}restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice. Helios-deficient Tregs develop an unstable phenotype during inflammatory responses characterized by reduced FoxP3 expression and increased effector cytokine expression secondary to diminished activation of the STAT5 pathway. CD8 Tregs also require Helios-dependent STAT5 activation for survival and to prevent terminal T cell differentiation. The definition of Helios as a key transcription factor that stabilizes Tregs in the face of inflammatory responses provides a genetic explanation for a core property of Tregs.",
author = "Kim, {Hye Jung} and Barnitz, {R. Anthony} and Taras Kreslavsky and Brown, {Flavian D.} and Howell Moffett and Lemieux, {Madeleine E.} and Yasemin Kaygusuz and Torsten Meissner and Holderried, {Tobias A.W.} and Susan Chan and Philippe Kastner and Haining, {W. Nicholas} and Harvey Cantor",
year = "2015",
month = oct,
day = "16",
doi = "10.1126/science.aad0616",
language = "English",
volume = "350",
pages = "334--339",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6258",
}
