Spontaneously forming unilamellar phospholipid vesicles

Baohua Yue; Chien Yueh Huang; Mu Ping Nieh; Charles J. Glinka; John Katsaras

doi:10.1002/masy.200550111

Spontaneously forming unilamellar phospholipid vesicles

Baohua Yue, Chien Yueh Huang, Mu Ping Nieh, Charles J. Glinka, John Katsaras

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Unilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.

Original language	English
Pages (from-to)	123-134
Number of pages	12
Journal	Macromolecular Symposia
Volume	219
DOIs	https://doi.org/10.1002/masy.200550111
State	Published - Dec 1 2004
Externally published	Yes

Keywords

Dynamic light scattering
Membranes
Neutron scattering
Phospholipids
Vesicles

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10.1002/masy.200550111

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abstract = "Unilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.",

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T1 - Spontaneously forming unilamellar phospholipid vesicles

AU - Yue, Baohua

AU - Huang, Chien Yueh

AU - Nieh, Mu Ping

AU - Glinka, Charles J.

AU - Katsaras, John

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Unilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.

AB - Unilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.

KW - Dynamic light scattering

KW - Membranes

KW - Neutron scattering

KW - Phospholipids

KW - Vesicles

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DO - 10.1002/masy.200550111

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VL - 219

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JO - Macromolecular Symposia

JF - Macromolecular Symposia

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Spontaneously forming unilamellar phospholipid vesicles

Abstract

Keywords

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