Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability

Mu Ping Nieh; V. A. Raghunathan; Chien Yueh Huang; Jeremy Pencer; Thad Harroun; John Katsaras

Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability

Mu Ping Nieh, V. A. Raghunathan, Chien Yueh Huang, Jeremy Pencer, Thad Harroun, John Katsaras

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Unilamellar vesicles (ULV) made up of biologically relevant materials can serve as carriers for drug delivery or gene therapy. Compared to extrusion and sonication, methods traditionally used for producing ULV, spontaneous formation offers a cost-effective alternative for ULV mass production. Moreover, the fact that these ULV are most likely, thermodynamically stable assures that the final product will have an extended shelf life. Here we report recent work on ULV formed from long- and short-chain phospholipids (i.e., di 14:0 and di 6:0 phosphatidylcholine), and address some of the important factors that affect their polydispersity, size, shape and stability.

Original language	English
Title of host publication	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages	709-712
Number of pages	4
State	Published - 2006
Externally published	Yes
Event	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006

Publication series

Name	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume	2

Conference

Conference	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Country/Territory	United States
City	Boston, MA
Period	05/7/06 → 05/11/06

Keywords

Anti-cancer drug delivery
DHPC
DMPC
Nano particles
Phospholipids
Polydispersity
Small angle neutron scattering
Unilamellar vesicles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Nieh, M. P., Raghunathan, V. A., Huang, C. Y., Pencer, J., Harroun, T., & Katsaras, J. (2006). Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (pp. 709-712). (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 2).

Nieh, Mu Ping ; Raghunathan, V. A. ; Huang, Chien Yueh et al. / Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability. 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006. pp. 709-712 (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings).

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title = "Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability",

abstract = "Unilamellar vesicles (ULV) made up of biologically relevant materials can serve as carriers for drug delivery or gene therapy. Compared to extrusion and sonication, methods traditionally used for producing ULV, spontaneous formation offers a cost-effective alternative for ULV mass production. Moreover, the fact that these ULV are most likely, thermodynamically stable assures that the final product will have an extended shelf life. Here we report recent work on ULV formed from long- and short-chain phospholipids (i.e., di 14:0 and di 6:0 phosphatidylcholine), and address some of the important factors that affect their polydispersity, size, shape and stability.",

keywords = "Anti-cancer drug delivery, DHPC, DMPC, Nano particles, Phospholipids, Polydispersity, Small angle neutron scattering, Unilamellar vesicles",

author = "Nieh, {Mu Ping} and Raghunathan, {V. A.} and Huang, {Chien Yueh} and Jeremy Pencer and Thad Harroun and John Katsaras",

year = "2006",

language = "English",

isbn = "0976798573",

series = "2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings",

pages = "709--712",

booktitle = "2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings",

note = "2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings ; Conference date: 07-05-2006 Through 11-05-2006",

}

Nieh, MP, Raghunathan, VA, Huang, CY, Pencer, J, Harroun, T & Katsaras, J 2006, Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability. in 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, vol. 2, pp. 709-712, 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, Boston, MA, United States, 05/7/06.

Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability. / Nieh, Mu Ping; Raghunathan, V. A.; Huang, Chien Yueh et al.
2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006. p. 709-712 (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Raghunathan, V. A.

AU - Huang, Chien Yueh

AU - Pencer, Jeremy

AU - Harroun, Thad

AU - Katsaras, John

PY - 2006

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AB - Unilamellar vesicles (ULV) made up of biologically relevant materials can serve as carriers for drug delivery or gene therapy. Compared to extrusion and sonication, methods traditionally used for producing ULV, spontaneous formation offers a cost-effective alternative for ULV mass production. Moreover, the fact that these ULV are most likely, thermodynamically stable assures that the final product will have an extended shelf life. Here we report recent work on ULV formed from long- and short-chain phospholipids (i.e., di 14:0 and di 6:0 phosphatidylcholine), and address some of the important factors that affect their polydispersity, size, shape and stability.

KW - Anti-cancer drug delivery

KW - DHPC

KW - DMPC

KW - Nano particles

KW - Phospholipids

KW - Polydispersity

KW - Small angle neutron scattering

KW - Unilamellar vesicles

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M3 - Conference contribution

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T3 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

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BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

T2 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

Y2 - 7 May 2006 through 11 May 2006

ER -

Nieh MP, Raghunathan VA, Huang CY, Pencer J, Harroun T, Katsaras J. Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. 2006. p. 709-712. (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings).

Spontaneously forming unilamellar nano-sized vesicles - Polydispersity, size, shape and stability

Abstract

Publication series

Conference

Keywords

UN SDGs

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