Solvent effects on protein fast dynamics: Implications for biopreservation

Victoria García Sakai; Sheila Khodadadi; Marcus T. Cicerone; Joseph E. Curtis; Alexei P. Sokolov; Joon Ho Roh

doi:10.1039/c3sm50492a

Solvent effects on protein fast dynamics: Implications for biopreservation

Victoria García Sakai
, Sheila Khodadadi
, Marcus T. Cicerone
, Joseph E. Curtis
, Alexei P. Sokolov
, Joon Ho Roh

Soft Materials and Membranes

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.

Original language	English
Pages (from-to)	5336-5340
Number of pages	5
Journal	Soft Matter
Volume	9
Issue number	22
DOIs	https://doi.org/10.1039/c3sm50492a
State	Published - Jun 14 2013

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title = "Solvent effects on protein fast dynamics: Implications for biopreservation",

abstract = "In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.",

author = "Sakai, \{Victoria Garc{\'i}a\} and Sheila Khodadadi and Cicerone, \{Marcus T.\} and Curtis, \{Joseph E.\} and Sokolov, \{Alexei P.\} and Roh, \{Joon Ho\}",

year = "2013",

month = jun,

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doi = "10.1039/c3sm50492a",

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journal = "Soft Matter",

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T1 - Solvent effects on protein fast dynamics

T2 - Implications for biopreservation

AU - Sakai, Victoria García

AU - Khodadadi, Sheila

AU - Cicerone, Marcus T.

AU - Curtis, Joseph E.

AU - Sokolov, Alexei P.

AU - Roh, Joon Ho

PY - 2013/6/14

Y1 - 2013/6/14

N2 - In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.

AB - In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.

UR - https://www.scopus.com/pages/publications/84878116187

U2 - 10.1039/c3sm50492a

DO - 10.1039/c3sm50492a

M3 - Article

AN - SCOPUS:84878116187

SN - 1744-683X

VL - 9

SP - 5336

EP - 5340

JO - Soft Matter

JF - Soft Matter

IS - 22

ER -

Solvent effects on protein fast dynamics: Implications for biopreservation

Abstract

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