Solvent effects on protein fast dynamics: Implications for biopreservation

Victoria García Sakai; Sheila Khodadadi; Marcus T. Cicerone; Joseph E. Curtis; Alexei P. Sokolov; Joon Ho Roh

doi:10.1039/c3sm50492a

Solvent effects on protein fast dynamics: Implications for biopreservation

Victoria García Sakai, Sheila Khodadadi, Marcus T. Cicerone, Joseph E. Curtis, Alexei P. Sokolov, Joon Ho Roh

Soft Materials and Membranes

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.

Original language	English
Pages (from-to)	5336-5340
Number of pages	5
Journal	Soft Matter
Volume	9
Issue number	22
DOIs	https://doi.org/10.1039/c3sm50492a
State	Published - Jun 14 2013

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title = "Solvent effects on protein fast dynamics: Implications for biopreservation",

abstract = "In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.",

author = "Sakai, {Victoria Garc{\'i}a} and Sheila Khodadadi and Cicerone, {Marcus T.} and Curtis, {Joseph E.} and Sokolov, {Alexei P.} and Roh, {Joon Ho}",

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T2 - Implications for biopreservation

AU - Sakai, Victoria García

AU - Khodadadi, Sheila

AU - Cicerone, Marcus T.

AU - Curtis, Joseph E.

AU - Sokolov, Alexei P.

AU - Roh, Joon Ho

PY - 2013/6/14

Y1 - 2013/6/14

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AB - In the context of biopreservation, we study the influence of water, glycerol and trehalose on the ps-ns dynamics of lyzosyme using neutron scattering. Results indicate that the choice of bioprotectant depends on the storage temperature; glycerol is the most effective for low temperatures and trehalose for high temperatures.

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U2 - 10.1039/c3sm50492a

DO - 10.1039/c3sm50492a

M3 - Article

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VL - 9

SP - 5336

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JO - Soft Matter

JF - Soft Matter

IS - 22

ER -

Solvent effects on protein fast dynamics: Implications for biopreservation

Abstract

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