Soft-templated mesoporous carbons as potential materials for oral drug delivery

Dipendu Saha; Kaitlyn E. Warren; Amit K. Naskar

doi:10.1016/j.carbon.2014.01.005

Soft-templated mesoporous carbons as potential materials for oral drug delivery

Dipendu Saha, Kaitlyn E. Warren, Amit K. Naskar

Carbon and Composites

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86 Scopus citations

Abstract

Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride (HCl). Captopril and furosemide exhibited desorption kinetics over 30-40 h, and ranitidine. HCl had a complete release time of 5-10 h. As evident from the slow release kinetics, the mesoporous carbons have excellent potential for the controlled-release media of the specific drugs targeted towards oral delivery. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200-400 m² g^-1 and pore volume of 0.2-0.6 cm³ g^-1. The synthetic carbon has narrower pore widths and higher pore volume than the renewable counterpart and maintains a longer release time. The release kinetics reveals that the diffusivities of the drugs from carbon media are of equivalent magnitude (10^-22 to 10^-24 m² s^-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecule by an order of magnitude. Thus, engineered pore morphology, along with its functionalization potential for specific interaction, can be exploited for optimal delivery system of a preferred drug.

Original language	English
Pages (from-to)	47-57
Number of pages	11
Journal	Carbon
Volume	71
DOIs	https://doi.org/10.1016/j.carbon.2014.01.005
State	Published - May 2014

Funding

Research was sponsored by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory (ORNL) , managed by UT-Battelle, LLC , for the U.S. Department of Energy. Small-angle x-ray scattering (SAXS) instrumentation was sponsored by the Scientific User Facility Division, Office of Basic Energy Sciences, U.S . Department of Energy. The authors also acknowledge the assistance with instrumentation provided by Dr. Gerald (Jay) E. Jellison for UV-Vis spectroscopy and by Dr. E. Andrew Payzant for SAXS (both of ORNL). K.E.W. acknowledges the DOE-SULI program for a summer internship in the Materials Science and Technology Division, ORNL.

Funders	Funder number
U.S. Department of Energy
Basic Energy Sciences
Oak Ridge National Laboratory
UT-Battelle

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title = "Soft-templated mesoporous carbons as potential materials for oral drug delivery",

abstract = "Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride (HCl). Captopril and furosemide exhibited desorption kinetics over 30-40 h, and ranitidine. HCl had a complete release time of 5-10 h. As evident from the slow release kinetics, the mesoporous carbons have excellent potential for the controlled-release media of the specific drugs targeted towards oral delivery. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200-400 m2 g-1 and pore volume of 0.2-0.6 cm3 g-1. The synthetic carbon has narrower pore widths and higher pore volume than the renewable counterpart and maintains a longer release time. The release kinetics reveals that the diffusivities of the drugs from carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecule by an order of magnitude. Thus, engineered pore morphology, along with its functionalization potential for specific interaction, can be exploited for optimal delivery system of a preferred drug.",

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AB - Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride (HCl). Captopril and furosemide exhibited desorption kinetics over 30-40 h, and ranitidine. HCl had a complete release time of 5-10 h. As evident from the slow release kinetics, the mesoporous carbons have excellent potential for the controlled-release media of the specific drugs targeted towards oral delivery. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200-400 m2 g-1 and pore volume of 0.2-0.6 cm3 g-1. The synthetic carbon has narrower pore widths and higher pore volume than the renewable counterpart and maintains a longer release time. The release kinetics reveals that the diffusivities of the drugs from carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecule by an order of magnitude. Thus, engineered pore morphology, along with its functionalization potential for specific interaction, can be exploited for optimal delivery system of a preferred drug.

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Soft-templated mesoporous carbons as potential materials for oral drug delivery

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