Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity

Kun Qin; Shuren Hu; Scott T.R. Etterer; Ivan I. Kravchenko; Sharon M. Weiss

doi:10.1364/OL.41.000753

Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity

Kun Qin, Shuren Hu, Scott T.R. Etterer, Ivan I. Kravchenko, Sharon M. Weiss

Nanofabrication Research Laboratory

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The design, fabrication, and characterization of a label-free Mach-Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeterlength sensing regions. An experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.

Original language	English
Pages (from-to)	753-756
Number of pages	4
Journal	Optics Letters
Volume	41
Issue number	4
DOIs	https://doi.org/10.1364/OL.41.000753
State	Published - Feb 15 2016

Funding

Funding. National Science Foundation (NSF) (ECCS-0925642, ECCS-1407777).

Funders	Funder number
National Science Foundation	ECCS-0925642, ECCS-1407777
Horizon 2020 Framework Programme	644242

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title = "Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity",

abstract = "The design, fabrication, and characterization of a label-free Mach-Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeterlength sensing regions. An experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.",

author = "Kun Qin and Shuren Hu and Etterer, {Scott T.R.} and Kravchenko, {Ivan I.} and Weiss, {Sharon M.}",

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AU - Kravchenko, Ivan I.

AU - Weiss, Sharon M.

PY - 2016/2/15

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AB - The design, fabrication, and characterization of a label-free Mach-Zehnder interferometer (MZI) optical biosensor that incorporates a highly dispersive one-dimensional (1D) photonic crystal in one arm are presented. The sensitivity of this slow light MZI-based sensor scales with the length of the slow light photonic crystal region. The numerically simulated sensitivity of a MZI sensor with a 16 μm long slow light region is 115,000 rad/RIU-cm, which is sevenfold higher than traditional MZI biosensors with millimeterlength sensing regions. An experimental bulk refractive index detection sensitivity of 84,000 rad/RIU-cm is realized and nucleic acid detection is also demonstrated.

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Slow light Mach-Zehnder interferometer as label-free biosensor with scalable sensitivity

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