Size and shape affects the antimicrobial activity of quaternized nanoparticles

Maria Inam; Jeffrey C. Foster; Jingyi Gao; Yuanxiu Hong; Jianzhong Du; Andrew P. Dove; Rachel K. O'Reilly

doi:10.1002/pola.29195

Size and shape affects the antimicrobial activity of quaternized nanoparticles

Maria Inam, Jeffrey C. Foster, Jingyi Gao, Yuanxiu Hong, Jianzhong Du, Andrew P. Dove, Rachel K. O'Reilly

Soft Materials and Membranes

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Researchers reported the anti-bacterial activity of quaternized poly(L-lactide)-block (PLLA-b)-PDMAEMA block copolymers assembled into spherical particles and diamond-shaped platelets of twodifferent sizes using a crystallization-driven self-assembly (CDSA) approach. H NMR spectroscopic analysis was used to confirm the degree of polymerization and a narrow dispersity of the polymer and monomodal distribution was confirmed by size exclusion chromatography refractive index analysis, with good overlap of the ultraviolet trace showing retention of the RAFT chain transfer agent (CTA) end group. A series of cationically-charged nanostructures were prepared using both CDSA and conventional self-assembly. Diamond-shaped platelets were prepared by heating the polymer in a sealed vial for 4 h before cooling to room temperature and ageing for 1 day. Semicrystalline platelets were formed as confirmed by transmission electron microscopy (TEM) and wide-angle X-ray diffraction analysis.

Original language	English
Pages (from-to)	255-259
Number of pages	5
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	57
Issue number	3
DOIs	https://doi.org/10.1002/pola.29195
State	Published - Feb 1 2019

Funding

The authors would like to thank the ERC (615142), EPSRC, Royal Society, and NSFC (21674081) for funding.

Keywords

biological activity
platelets
polymers
self-assembly
size effects

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10.1002/pola.29195

Cite this

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title = "Size and shape affects the antimicrobial activity of quaternized nanoparticles",

abstract = "Researchers reported the anti-bacterial activity of quaternized poly(L-lactide)-block (PLLA-b)-PDMAEMA block copolymers assembled into spherical particles and diamond-shaped platelets of twodifferent sizes using a crystallization-driven self-assembly (CDSA) approach. H NMR spectroscopic analysis was used to confirm the degree of polymerization and a narrow dispersity of the polymer and monomodal distribution was confirmed by size exclusion chromatography refractive index analysis, with good overlap of the ultraviolet trace showing retention of the RAFT chain transfer agent (CTA) end group. A series of cationically-charged nanostructures were prepared using both CDSA and conventional self-assembly. Diamond-shaped platelets were prepared by heating the polymer in a sealed vial for 4 h before cooling to room temperature and ageing for 1 day. Semicrystalline platelets were formed as confirmed by transmission electron microscopy (TEM) and wide-angle X-ray diffraction analysis.",

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AU - Inam, Maria

AU - Foster, Jeffrey C.

AU - Gao, Jingyi

AU - Hong, Yuanxiu

AU - Du, Jianzhong

AU - Dove, Andrew P.

AU - O'Reilly, Rachel K.

PY - 2019/2/1

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AB - Researchers reported the anti-bacterial activity of quaternized poly(L-lactide)-block (PLLA-b)-PDMAEMA block copolymers assembled into spherical particles and diamond-shaped platelets of twodifferent sizes using a crystallization-driven self-assembly (CDSA) approach. H NMR spectroscopic analysis was used to confirm the degree of polymerization and a narrow dispersity of the polymer and monomodal distribution was confirmed by size exclusion chromatography refractive index analysis, with good overlap of the ultraviolet trace showing retention of the RAFT chain transfer agent (CTA) end group. A series of cationically-charged nanostructures were prepared using both CDSA and conventional self-assembly. Diamond-shaped platelets were prepared by heating the polymer in a sealed vial for 4 h before cooling to room temperature and ageing for 1 day. Semicrystalline platelets were formed as confirmed by transmission electron microscopy (TEM) and wide-angle X-ray diffraction analysis.

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Size and shape affects the antimicrobial activity of quaternized nanoparticles

Abstract

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Keywords

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