Abstract
DNA was used as a scaffold for the binding of gold nanoparticles using a standard chemical technique. A DNA template was designed with amino-modified thymines located every 3.7 nm, which would allow the attachment of the carboxylic acid functionalized gold nanoparticles. The gold particles were covalently bound to the amino groups on the DNA using standard 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) chemistry in the presence of a competitor to block excess gold binding sites. The products were analyzed by transmission electron microscopy (TEM) and atomic force microscopy (AFM).
Original language | English |
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Pages (from-to) | C421-C424 |
Journal | Materials Research Society Symposium - Proceedings |
Volume | 635 |
DOIs | |
State | Published - 2001 |
Event | Anisotropic Nanoparticles-Synthesis, Characterization and Applications - Boston, MA, United States Duration: Nov 27 2000 → Nov 29 2000 |
Funding
This research was supported by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory. Oak Ridge National Laboratory is managed by UT-Battelle, LLC, for the U. S. Department of Energy under contract DE-AC05-00OR22725.