siRNA nanomedicine for cancer therapy

Sun Hwa Kim; Tae Gwan Park

siRNA nanomedicine for cancer therapy

Sun Hwa Kim, Tae Gwan Park

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

A polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for treatment of cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating prostate cancer cells with the PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovascularization and tumor growth in animals with PC-3 tumor xenograft.

Original language	English
Title of host publication	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages	770-771
Number of pages	2
State	Published - 2007
Externally published	Yes
Event	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States Duration: May 20 2007 → May 24 2007

Publication series

Name	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume	2

Conference

Conference	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
Country/Territory	United States
City	Santa Clara, CA
Period	05/20/07 → 05/24/07

Keywords

Cancer gene therapy
Polyelectrolyte complex micelle
VEGF
siRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@inproceedings{6f49ff72f0fa4731b84d733819b1c7a3,

title = "siRNA nanomedicine for cancer therapy",

abstract = "A polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for treatment of cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating prostate cancer cells with the PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovascularization and tumor growth in animals with PC-3 tumor xenograft.",

keywords = "Cancer gene therapy, Polyelectrolyte complex micelle, VEGF, siRNA",

author = "Kim, {Sun Hwa} and Park, {Tae Gwan}",

year = "2007",

language = "English",

isbn = "1420063421",

series = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",

pages = "770--771",

booktitle = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",

note = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 ; Conference date: 20-05-2007 Through 24-05-2007",

}

Kim, SH & Park, TG 2007, siRNA nanomedicine for cancer therapy. in 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings, vol. 2, pp. 770-771, 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Santa Clara, CA, United States, 05/20/07.

siRNA nanomedicine for cancer therapy. / Kim, Sun Hwa; Park, Tae Gwan.
2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. 2007. p. 770-771 (2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - siRNA nanomedicine for cancer therapy

AU - Kim, Sun Hwa

AU - Park, Tae Gwan

PY - 2007

Y1 - 2007

N2 - A polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for treatment of cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating prostate cancer cells with the PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovascularization and tumor growth in animals with PC-3 tumor xenograft.

AB - A polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for treatment of cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating prostate cancer cells with the PEC micelles formed from the interaction between the conjugate and polyethylenimine (PEI). The efficient hVEGF gene silencing by hVEGF siRNA-PEG/PEI complexes dramatically suppressed tumor neovascularization and tumor growth in animals with PC-3 tumor xenograft.

KW - Cancer gene therapy

KW - Polyelectrolyte complex micelle

KW - VEGF

KW - siRNA

UR - http://www.scopus.com/inward/record.url?scp=34547991780&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:34547991780

SN - 1420063421

SN - 9781420063424

SN - 1420061836

SN - 9781420061833

T3 - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

SP - 770

EP - 771

BT - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

T2 - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007

Y2 - 20 May 2007 through 24 May 2007

ER -

siRNA nanomedicine for cancer therapy

Abstract

Publication series

Conference

Keywords

UN SDGs

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